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Details

Stereochemistry RACEMIC
Molecular Formula C11H12N2O3.H2O
Molecular Weight 238.2399
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 5-HYDROXYTRYPTOPHAN MONOHYDRATE, DL-

SMILES

O.NC(CC1=CNC2=C1C=C(O)C=C2)C(O)=O

InChI

InChIKey=UIHHMHBYEZJGNC-UHFFFAOYSA-N
InChI=1S/C11H12N2O3.H2O/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10;/h1-2,4-5,9,13-14H,3,12H2,(H,15,16);1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C11H12N2O3
Molecular Weight 220.2246
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Sources: DOI: 10.1016/S0079-6123(08)60124-7
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3128339

DL-5-hydroxytryptophan, 5-HTP is a serotonin precursor. It was discovered on the rats, that the pharmacological responses and changes in brain 5-hydroxytryptamine (5-HT) concentration elicited following the administration of 5-HTP did not reflect changes in the concentration of endogenous brain 5-HT. The biochemical and pharmacological properties of the 5-HTP-induced increases in brain 5-HT concentration were distinctly different from those of increases in the endogenous content of the amine. In normal rats, administered 5-HTP, observable pharmacological responses were not elicited, despite equal or even larger increases in brain 5-HT concentration.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
The effects of DL-5-hydroxytryptophan on ethanol consumption by rats.
1978 Apr

Sample Use Guides

In Vivo Use Guide
for rats: DL-5-hydroxytryptophan (5HTP) in doses of 50, 100 or 200 mg/kg was injected intraperitoneally one hour prior to the drinking session.
Route of Administration: Intraperitoneal
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:07:12 GMT 2023
Edited
by admin
on Fri Dec 15 15:07:12 GMT 2023
Record UNII
XXE58DJG85
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
5-HYDROXYTRYPTOPHAN MONOHYDRATE, DL-
Common Name English
5-HYDROXY TRYPTOPHAN MONOHYDRATE,DL-
Common Name English
5-HYDROXY TRYPTOPHAN MONOHYDRATE, DL-
Common Name English
5-HYDROXY-DL-TRYPTOPHAN MONOHYDRATE
Systematic Name English
Code System Code Type Description
FDA UNII
XXE58DJG85
Created by admin on Fri Dec 15 15:07:12 GMT 2023 , Edited by admin on Fri Dec 15 15:07:12 GMT 2023
PRIMARY
CAS
10030-79-2
Created by admin on Fri Dec 15 15:07:12 GMT 2023 , Edited by admin on Fri Dec 15 15:07:12 GMT 2023
PRIMARY
PUBCHEM
45052530
Created by admin on Fri Dec 15 15:07:12 GMT 2023 , Edited by admin on Fri Dec 15 15:07:12 GMT 2023
PRIMARY
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