U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 201 - 210 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol (N,N-didesmethylvenlafaxine, also known as Venlafaxine EP Impurity C) is an intermediate in the synthesis of N,O-Didesmethylvenlafaxine and a metabolite of Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI).
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Diethanolammonium Linoleate is ionic compound, room-temperature ionic liquid, that used as environmentally friendly surfactant and corrosion inhibitor.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Narwedine, (±)- is an immediate precursor to the therapeutically valuable alkaloid (-)-galanthamine. Galantamine is a competitive and reversible cholinesterase inhibitor used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. Narwedine pronounced antinarcotic action, facilitates the transmission of nervous excitation in n- and mcholinergic synapses. Stimulates respiration and possessed a brief hypotensive effect.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

(+)-Galanthamine is an alkaloid benzazepine derived from norbelladine. In contrast to the (-)-Galanthamine, (+)-Galanthamine demonstrates substantially lower biological activity.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

25CN-NBOH (or NBOH-2C-CN) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2011 by Martin Hansen at the University of Copenhagen. This compound is notable as one of the most selective agonist ligands for the 5-HT2A receptor yet discovered, with a pKi of 8.88 at the human 5-HT2A receptor and with 100x selectivity for 5-HT2A over 5-HT2C, and 46x selectivity for 5-HT2A over 5-HT2B
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Methyl beta-carboline-3-carboxylate (beta-CCM or beta-carboline-3 carboxylic acid methyl ester) is an inverse agonist of benzodiazepine site of GABA-A receptor. Experiments on rats have shown that beta-CCM does not reverse learning deficit induced by sleep deprivation.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

5-OH-JWH-018 is a major urinary metabolite of JWH 018, a mildly selective agonist of the peripheral cannabinoid (CB2) receptor. 5-OH-JWH-018 is characterized by monohydroxylation of the N-alkyl chain, which is almost completely glucuronidated in urine samples.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA) is a high-affinity, reversible and selective orexin type 2 (OX2) receptor antagonist. The in vivo activity of EMPA was assessed by reversal of orexin-B-induced hyperlocomotion during the resting phase in mice and the reduction of spontaneous locomotor activity (LMA) during the active phase in rats.
U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". U 89843A has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Drospirenone acid is a metabolite of drospirenone, one of the two main metabolites found in human plasma. Drospirenone is a synthetic progestational compound used as a component of oral contraceptive in combination with ethinyl estradiol (YASMIN®) or ethinyl estradiol/levomefolate calcium (BEYAZ®).