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Showing 1 - 10 of 63 results

Status:
US Approved Rx (2020)
First approved in 2020

Class (Stereo):
CHEMICAL (ABSOLUTE)



Sodium artesunate, an artemisinin derivative, is used in malaria treatment. Artesunate, has been licensed in Thailand for the treatment of falciparum malaria since 1990. It is a potent antimalarial drug that can reduce parasitaemia by 90% within 24 h...
Status:
US Approved Rx (2009)
First approved in 2009

Class (Stereo):
CHEMICAL (ABSOLUTE)



Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy against malaria. Artemether is rapidly metabolized into an active metabolite dihydroartemisinin (...
Status:
US Approved Rx (2011)
First approved in 1947

Class (Stereo):
CHEMICAL (ACHIRAL)



Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. Proguanil in combination with atovaquone are marked under the...
Status:
US Approved Rx (2010)
First marketed in 1921

Class (Stereo):
CHEMICAL (ABSOLUTE)



Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart. It is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as...
Status:
US Approved Rx (1939)
First marketed in 1921

Class (Stereo):
CHEMICAL (ABSOLUTE)



QUALAQUIN (quinine sulfate) is an antimalarial drug indicated only for treatment of uncomplicated Plasmodium falciparum malaria. It’s an alkaloid derived from the bark of the cinchona tree and is the active ingredient in extracts of the cinchona that...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



Artefenomel, a novel trioxolane, is a lead candidate for inclusion in a new antimalarial combination, specifically formulated for children. Artefenomel has been demonstrated curative in as little as one dose.
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



Cycloheximide is an antibiotic produced by fermentation culture of Streptomyces griseus, Streptomyces noursei, Streptomyces albulus, Streptomyces naraensis, or other cycloheximide-producing microorganism. It was first discovered by A. Whiffen et al. ...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Temefos (Diphos, Temephos) is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase...
MDL-201053, (DL-ALANINE)- (Z-FA-FMK) is an irreversible inhibitor of cysteine proteases, such as cathepsin B, L, and S. The compound has also inhibitited papain and cruzain. Z-FA-FMK has been shown to selectively inhibit effector caspase-2, caspase-3...
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)



Rutarin is a coumarin glycoside. Rutarin is found in herbs and spices. Rutarin has antibiotic activity. Rutarin inhibited Plasmodium falciparum with IC50 value of 88 ug/mL.