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Showing 1 - 10 of 100 results

Status:
US Approved Rx (2023)
First approved in 2009

Class (Stereo):
CHEMICAL (ABSOLUTE)



Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. It belongs to the second-generation piperidine chemical class. It is a mast cell stabilizer and suppresses the migration of eosinophils into inflamed tissues. Bepot...
Status:
US Approved Rx (2013)
First approved in 1995

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levocetirizine is the active enantiomer of cetirizine. It is inverse agonist of H1 receptors. Levocetirizine hydrochloride was approved for treatment of Allergic Rhinitis and Chronic Idiopathic Urticaria.
Status:
US Approved Rx (2018)
First approved in 1988

Class (Stereo):
CHEMICAL (RACEMIC)



Cetirizine, a human metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. It is indicated for the relief of nasal and non-nasal symptoms associated with seasonal or per...
Status:
US Approved Rx (1994)
First approved in 1977

Class (Stereo):
CHEMICAL (ABSOLUTE)



Clemastine is an antihistamine with anticholinergic (drying) and sedative side effects. Clemastine is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads...
Status:
US Approved Rx (2000)
First approved in 1973

Class (Stereo):
CHEMICAL (ACHIRAL)



Cromolyn is a mast cell stabilizer. In vitro and in vivo animal studies have shown that cromolyn sodium inhibits the degranulation of sensitized mast cells, which occurs after exposure to specific antigens. Cromolyn sodium acts by inhibiting the rele...
Status:
US Approved Rx (2020)
First approved in 1961

Class (Stereo):
CHEMICAL (ABSOLUTE)



Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage ad...
Status:
US Approved OTC
First approved in 2014

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levomethamphetamine is the levorotary (L-enantiomer) form of methamphetamine. Levomethamphetamine is a sympathomimetic vasoconstrictor which is the active ingredient in some over-the-counter (OTC) nasal decongestant inhalers in the United States. Le...
Status:
US Approved OTC
First approved in 1959

Class (Stereo):
CHEMICAL (ABSOLUTE)



DEXBROMPHENIRAMINE is an alkylamine derivative with anticholinergic and sedative properties. It is a histamine H1-receptor antagonist that competes with histamine for the H1-receptor sites on effector cells in the gastrointestinal tract, blood vessel...
Status:
US Approved OTC
First approved in 1959

Class (Stereo):
CHEMICAL (ACHIRAL)



Xylometazoline, also spelled xylomethazoline, is a medication which is used to improve symptoms of nasal congestion, allergic rhinitis, and sinusitis. Xylometazoline was patented in 1956 and came into medical use in 1959. It is on the World Health O...
Status:
US Approved OTC
First approved in 1949

Class (Stereo):
CHEMICAL (RACEMIC)



Chlorpheniramine is an antihistamine. Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Chlorpheniramine...