BETAMETHASONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29FO5
Molecular Weight	392.4611
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=UREBDLICKHMUKA-DVTGEIKXSA-N

InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.drugbank.ca/drugs/DB00443

Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.Betamethasone is used for: treating certain conditions associated with decreased adrenal gland function. It is used to treat severe inflammation caused by certain conditions, including severe asthma, severe allergies, rheumatoid arthritis, ulcerative colitis, certain blood disorders, lupus, multiple sclerosis, and certain eye and skin conditions.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: https://www.drugbank.ca/drugs/DB00443 \| https://www.ncbi.nlm.nih.gov/pubmed/12188035	Agonist 2678		1.3 nM [EC50]

Conditions

Condition	Modality	Highest Phase	Product
Asthma 241 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/014602s059lbl.pdf	Primary	Approved 8429	CELESTONE SOLUSPAN Approved Use When oral therapy is not feasible, the intramuscular use of CELESTONE SOLUSPAN Injectable Suspension is indicated as follows: Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine Disorders Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal Diseases To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis. Hematologic Disorders Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia. Miscellaneous Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Neoplastic Diseases For palliative management of leukemias and lymphomas. Nervous System Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Ophthalmic Diseases Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal Diseases To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus. Respiratory Diseases Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus. Launch Date 1961
Allergic rhinitis 100 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/014602s059lbl.pdf	Primary	Approved 8429	CELESTONE SOLUSPAN Approved Use When oral therapy is not feasible, the intramuscular use of CELESTONE SOLUSPAN Injectable Suspension is indicated as follows: Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine Disorders Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal Diseases To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis. Hematologic Disorders Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia. Miscellaneous Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Neoplastic Diseases For palliative management of leukemias and lymphomas. Nervous System Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Ophthalmic Diseases Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal Diseases To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus. Respiratory Diseases Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus. Launch Date 1961
Congenital adrenal hyperplasia 41 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/014602s059lbl.pdf	Primary	Approved 8429	CELESTONE SOLUSPAN Approved Use When oral therapy is not feasible, the intramuscular use of CELESTONE SOLUSPAN Injectable Suspension is indicated as follows: Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine Disorders Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal Diseases To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis. Hematologic Disorders Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia. Miscellaneous Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Neoplastic Diseases For palliative management of leukemias and lymphomas. Nervous System Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Ophthalmic Diseases Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal Diseases To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus. Respiratory Diseases Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus. Launch Date 1961
Ulcerative colitis 123 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/014602s059lbl.pdf	Primary	Approved 8429	CELESTONE SOLUSPAN Approved Use When oral therapy is not feasible, the intramuscular use of CELESTONE SOLUSPAN Injectable Suspension is indicated as follows: Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine Disorders Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal Diseases To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis. Hematologic Disorders Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia. Miscellaneous Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Neoplastic Diseases For palliative management of leukemias and lymphomas. Nervous System Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Ophthalmic Diseases Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal Diseases To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus. Respiratory Diseases Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus. Launch Date 1961
Lymphomas 16 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/014602s059lbl.pdf	Palliative	Approved 8429	CELESTONE SOLUSPAN Approved Use When oral therapy is not feasible, the intramuscular use of CELESTONE SOLUSPAN Injectable Suspension is indicated as follows: Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine Disorders Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal Diseases To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis. Hematologic Disorders Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia. Miscellaneous Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Neoplastic Diseases For palliative management of leukemias and lymphomas. Nervous System Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Ophthalmic Diseases Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal Diseases To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus. Respiratory Diseases Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus. Launch Date 1961
Acute exacerbations of multiple sclerosis 13 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/014602s059lbl.pdf	Primary	Approved 8429	CELESTONE SOLUSPAN Approved Use When oral therapy is not feasible, the intramuscular use of CELESTONE SOLUSPAN Injectable Suspension is indicated as follows: Allergic States Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine Disorders Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal Diseases To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis. Hematologic Disorders Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia. Miscellaneous Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Neoplastic Diseases For palliative management of leukemias and lymphomas. Nervous System Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Ophthalmic Diseases Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal Diseases To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus. Respiratory Diseases Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus. Launch Date 1961

C_max

Value	Dose	Analyte	Population
76.8 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/31808984	6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
67.6 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/31808984	6 mg single, intramuscular dose: 6 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
101 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6662164/	8 mg single, intravenous dose: 8 mg route of administration: Intravenous experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
796 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/31808984	6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
811 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/31808984	6 mg single, intramuscular dose: 6 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
46.3 μg × min/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6662164/	8 mg single, intravenous dose: 8 mg route of administration: Intravenous experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
13.9 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/31808984	6 mg single, oral dose: 6 mg route of administration: Oral experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
10.2 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/31808984	6 mg single, intramuscular dose: 6 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
335 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6662164/	8 mg single, intravenous dose: 8 mg route of administration: Intravenous experiment type: SINGLE co-administered:	BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
36% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6662164/	8 mg single, intravenous dose: 8 mg route of administration: Intravenous experiment type: SINGLE co-administered:		BETAMETHASONE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
7.2 mg 1 times / day multiple, oral Highest studied dose Dose: 7.2 mg, 1 times / day Route: oral Route: multiple Dose: 7.2 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/014215s009s015lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/014215s009s015lbl.pdf	Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/014215s009s015lbl.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737 inhibitor 1587 inducer 781	inhibitor 1767 inducer 389	inhibitor 1852	inhibitor 1612

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 1524 CYP2A6 707 CYP2C19 1478 CYP2E1 882 OATP1B1 788 OATP1B3 706 BSEP 402 MRP2 383 MRP3 157 MRP4 204	CYP19A1 23 P-gp 1537	CYP3A5 76 CYP2A6 79 CYP1B1 51 CYP2B6 547 CYP2C8 168 CYP2C19 293 CYP3A7 15

Drug as perpetrator

Target	Modality	Activity
CYP1A2 1692	inhibitor 3277 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzMzU2IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDYzMiJ9fQ%3D%3D	no [IC50 >10 uM]
CYP2A6 739	inhibitor 3277 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkw1MjgyIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDYzMiJ9fQ%3D%3D	no [IC50 >10 uM]
CYP2C19 1553	inhibitor 3277 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzNjIyIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDYzMiJ9fQ%3D%3D	no [IC50 >10 uM]
CYP2C9 1819	inhibitor 3277 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzMzk3IiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDYzMiJ9fQ%3D%3D	no [IC50 >10 uM]
CYP2D6 1891	inhibitor 3277 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwyODkiLCJ1c2VfY3VzdG9tX3F1ZXJ5Ijp0cnVlLCJzZWFyY2hfdGVybSI6IiIsInRleHRfZmlsdGVyIjoiQ0hFTUJMNjMyIn19	no [IC50 >10 uM]
CYP2E1 970	inhibitor 3277 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkw1MjgxIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDYzMiJ9fQ%3D%3D	no [IC50 >10 uM]
CYP3A4 1925	inhibitor 3277 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwzNDAiLCJ1c2VfY3VzdG9tX3F1ZXJ5Ijp0cnVlLCJzZWFyY2hfdGVybSI6IiIsInRleHRfZmlsdGVyIjoiQ0hFTUJMNjMyIn19	no [IC50 >10 uM]
BSEP 403	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23956101/	no [IC50 >133 uM]
MRP2 475	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23956101/	no [IC50 >133 uM]
MRP3 207	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23956101/	no [IC50 >133 uM]
MRP4 238	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23956101/	no [IC50 >133 uM]
CYP2B6 1001	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443\| https://pubmed.ncbi.nlm.nih.gov/17101742/	no
CYP1B1 67	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443 \| https://pubmed.ncbi.nlm.nih.gov/24451000/	yes
CYP2A6 739	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443 \| https://pubmed.ncbi.nlm.nih.gov/24451000/	yes
CYP2C19 1553	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443 \| https://pubmed.ncbi.nlm.nih.gov/24451000/	yes
CYP2C8 965	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443 \| https://pubmed.ncbi.nlm.nih.gov/24451000/	yes
CYP2C9 1819	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443 \| https://pubmed.ncbi.nlm.nih.gov/24451000/	yes
CYP3A4 1925	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443\| https://pubmed.ncbi.nlm.nih.gov/22673009/	yes
CYP3A5 130	inducer 1573 Sources: https://go.drugbank.com/drugs/DB00443\| https://pubmed.ncbi.nlm.nih.gov/22673009/	yes
CYP3A7 22	inducer 1573 Sources: https://pubmed.ncbi.nlm.nih.gov/22673009/	yes
OATP1B1 803	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23571415/	yes
OATP1B3 715	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23571415/	yes

Drug as victim

Target	Modality	Activity	Clinical evidence
CYP19A1 23	substrate 3367 Sources: https://go.drugbank.com/drugs/DB00443\| https://go.drugbank.com/articles/A182870	yes
P-gp 1537	substrate 3367 Sources: https://go.drugbank.com/drugs/DB00443\| https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkw0MzAyIiwidXNlX2N1c3RvbV9xdWVyeSI6dHJ1ZSwic2VhcmNoX3Rlcm0iOiIiLCJ0ZXh0X2ZpbHRlciI6IkNIRU1CTDYzMiJ9fQ%3D%3D	yes
CYP3A4 1737	substrate 3367 Sources: https://go.drugbank.com/drugs/DB00443\| https://ncit-stage.nci.nih.gov/ncitbrowser/pages/concept_details.jsf?dictionary=NCI_Thesaurus&version=21.04d&code=C303&ns=ncit&type=relationship&key=1874461855&b=1&n=0&vse=null \| https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/762/original/1.pdf?1532386869	yes	yes (co-administration study) Comment: Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60%, leading to an increased risk of corticosteroid side effects. Sources: https://go.drugbank.com/drugs/DB00443\| https://ncit-stage.nci.nih.gov/ncitbrowser/pages/concept_details.jsf?dictionary=NCI_Thesaurus&version=21.04d&code=C303&ns=ncit&type=relationship&key=1874461855&b=1&n=0&vse=null \| https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/762/original/1.pdf?1532386869

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 1647	inhibitor 1626 Sources: https://www.ebi.ac.uk/chembl/g/#browse/activities/full_state/eyJsaXN0Ijp7InNldHRpbmdzX3BhdGgiOiJFU19JTkRFWEVTX05PX01BSU5fU0VBUkNILkFDVElWSVRZIiwiY3VzdG9tX3F1ZXJ5IjoidGFyZ2V0X2NoZW1ibF9pZDpDSEVNQkwyNDAiLCJ1c2VfY3VzdG9tX3F1ZXJ5Ijp0cnVlLCJzZWFyY2hfdGVybSI6IiIsInRleHRfZmlsdGVyIjoiQ0hFTUJMNjMyIn19

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:3077	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3077
ChemicalBook	CB7392335	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7392335
MolPort	MolPort-003-845-025	https://www.molport.com/shop/molecule-link/MolPort-003-845-025
Selleck Chemicals	Betamethasone-(Celestone)	http://www.selleckchem.com/products/Betamethasone-(Celestone).html
ZINC	ZINC000003876136	http://zinc15.docking.org/substances/ZINC000003876136
eMolecules	31224942	https://www.emolecules.com/cgi-bin/more?vid=31224942
eMolecules	535310	https://www.emolecules.com/cgi-bin/more?vid=535310

PubMed

Title	Date	PubMed
Treatment of psoriasis with a new combination of calcipotriol and betamethasone dipropionate: a flow cytometric study.	2001	11586014
Clinical evaluation of human placental extract (placentrex) in radiation-induced oral mucositis.	2001	11517852
[Rupture of the Achilles tendon after local steroid injection. Case reports and consequences for treatment].	2001	11515194
Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.	2001 Apr	11501509
Efficacy and tolerance of topical calcitriol 3 microg g(-1) in psoriasis treatment: a review of our experience in Poland.	2001 Apr	11501507
[Analysis of selected parameters of maternal and fetal status during stimulation of fetal lung maturation].	2001 Apr	11444174
A topical steroid without an antibiotic cures external otitis efficiently: a study in an animal model.	2001 Aug	11583468
Severe oral manifestations of chronic graft-vs.-host disease.	2001 Aug	11575020
The delivery of topical nasal sprays and drops to the middle meatus: a semiquantitative analysis.	2001 Aug	11559340
Single versus repeated-course antenatal corticosteroids: outcomes in singleton and multiple-gestation pregnancies.	2001 Aug	11552179
Most patients overdose on topical nasal corticosteroid drops: an accurate delivery device is required.	2001 Aug	11535143
Infantile acute hemorrhagic edema of the skin.	2001 Aug	11534914
Multiple courses of antenatal betamethasone and cognitive development of mice offspring.	2001 Aug	11531154
Painless thyroiditis induced by the cessation of betamethasone.	2001 Aug	11518115
Evaluation of the inhibitory activity of topical indomethacin, betamethasone valerate and emollients on UVL-induced inflammation by means of non-invasive measurements of the skin elasticity.	2001 Aug	11499541
Lichen planus-like eruption following autologous bone marrow transplantation for chronic myeloid leukaemia.	2001 Aug	11488713
Repeated prenatal corticosteroid administration delays astrocyte and capillary tight junction maturation in fetal sheep.	2001 Aug	11470378
Differentiation between dexamethasone and betamethasone in a mixture using multiple mass spectrometry.	2001 Aug 10	11554421
Comparative effects of calcipotriol and betamethasone 17-valerate solution in the treatment of seborrhoeic dermatitis of the scalp.	2001 Jan	11451340
Acute paronychia: comparative treatment with topical antibiotic alone or in combination with corticosteroid.	2001 Jan	11451337
Topical therapy with fluorinated and non-fluorinated corticosteroids in patients with atopic dermatitis.	2001 Jan	11451336
Systemic ketoconazole for yeast allergic patients with atopic dermatitis.	2001 Jan	11451319
Severe vulvovaginitis associated with intravaginal nystatin therapy.	2001 Jul	11483943
The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep.	2001 Jul	11483927
An evidence-based assessment of occlusal adjustment as a treatment for temporomandibular disorders.	2001 Jul	11458263
The effect of betamethasone versus dexamethasone on fetal biophysical parameters.	2001 Jul	11435009
Nonoperative treatment of an interosseous ganglion cyst.	2001 Jul	11421523
Valsalva retinopathy-like hemorrhage associated with combined trabeculotomy-trabeculectomy in a patient with developmental glaucoma.	2001 Jul-Aug	11475401
Tocolytic magnesium sulfate toxicity and unexpected neonatal death.	2001 Jun	11533846
Deleterious effects of local corticosteroid injections on the Achilles tendon of rats.	2001 Jun	11482466
Preliminary results of a pilot study investigating the potential of salivary cortisol measurements to detect occult adrenal suppression secondary to steroid nose drops.	2001 Jun	11437848
Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity.	2001 Jun	11411563
A prospective, randomized trial comparing the efficacy of dexamethasone and betamethasone for the treatment of antepartum HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome.	2001 Jun	11408849
Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids).	2001 Jun	11407316
Investigation of some commercially available spacer devices for the delivery of glucocorticoid steroids from a pMDI.	2001 May	11448047
[Pemphigoid gestationis: treatment by topical class I corticosteroid].	2001 May	11427799
Dermatitis during radiation for vulvar carcinoma: prevention and treatment with granulocyte-macrophage colony-stimulating factor impregnated gauze.	2001 May-Jun	11472614
Comparison of intramuscular betamethasone and oral prednisone in the prevention of relapse of acute asthma.	2001 May-Jun	11420590
Lumbar facet joint synovial cyst: percutaneous treatment with steroid injections and distention--clinical and imaging follow-up in 12 patients.	2001 Oct	11568337
Use of antenatal steroids to counteract the negative effects of tracheal occlusion in the fetal lamb model.	2001 Oct	11568293
Antenatal corticosteroids-too much of a good thing?	2001 Oct 3	11585487
Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: A randomized controlled trial.	2001 Oct 3	11585480
Growth and development of children to 4 years of age after repeated antenatal steroid administration.	2001 Sep	11585078
Repeated antenatal corticosteroid treatments. Do they reduce neonatal morbidity?	2001 Sep	11584477
Effects of antiinflammatory drugs on migration of the rabbit corneal epithelium.	2001 Sep	11566537
Manipulation under anesthesia for frozen shoulder with and without steroid injection.	2001 Sep	11552189
Multiple courses of antenatal steroids: risks and benefits.	2001 Sep	11530136
Fetal monkey surfactants after intra-amniotic or maternal administration of betamethasone and thyroid hormone.	2001 Sep	11530131
Treatment of childhood phimosis with a moderately potent topical steroid.	2001 Sep	11527265
Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure.	2001 Sep	11507014

Patents

Sample Use Guides

In Vivo Use Guide

The initial dosage of parenterally administered Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension may vary from 0.25 to 9 mg per day depending on the specific disease entity being treated. However, in certain overwhelming, acute, life-threatening situations, administrations in dosages exceeding the usual dosages may be justified and may be in multiples of the oral dosages. In the treatment of acute exacerbations of multiple sclerosis, daily doses of 30 mg of betamethasone for a week followed by 12 mg every other day for 1 month are recommended.In pediatric patients, the initial dose of betamethasone may vary depending on the specific disease entity being treated. The range of initial doses is 0.02 to 0.3 mg/kg/day in three or four divided doses (0.6 to 9 mg/m2bsa/day).

Route of Administration: Parenteral

In Vitro Use Guide

Betamethasone (10(-6)M) significantly reduced both pH 6-induced bronchial response and CGRP-like immunoreactivity overflow in guinea-pig isolated perfused lung.

Name

Type

Language

BETAMETHASONE

Official Name

English

VISUBETA

Code

English

FLOSTERON

Common Name

English

BETAMETHASONE [VANDF]

Common Name

English

FLUBENISOLONE

Common Name

English

BETAMETHASONE [JAN]

Common Name

English

SCH-4831

Code

English

BETAMETHASONE DIPROPIONATE IMPURITY A

Common Name

English

RINDERON

Brand Name

English

BETAMETHASONUM [WHO-IP LATIN]

Common Name

English

SCH 4831

Code

English

BETAMETHASONE VALERATE IMPURITY A [EP IMPURITY]

Common Name

English

BETAMETHASONE [WHO-IP]

Common Name

English

BETAMETHASONE [MART.]

Common Name

English

CELESTONE

Brand Name

English

BETAMETHASONE [MI]

Common Name

English

BETAMETHASONE [USP-RS]

Common Name

English

BETAMETHASONE [USAN]

Common Name

English

NSC-39470

Code

English

DESACORT-BETA

Common Name

English

betamethasone [INN]

Common Name

English

CELESTENE

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-, (11.BETA.,16.BETA.)-

Systematic Name

English

BETAMETHASONE ACETATE IMPURITY A [EP IMPURITY]

Common Name

English

Betamethasone [WHO-DD]

Common Name

English

BETAMETHASONE [EP IMPURITY]

Common Name

English

DEXAMETHASONE IMPURITY B [EP IMPURITY]

Common Name

English

9-FLUORO-11.BETA.,17,21-TRIHYDROXY-16.BETA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE.

Systematic Name

English

BETAMETHASONE [USP MONOGRAPH]

Common Name

English

BETAMETHASONE [EP MONOGRAPH]

Common Name

English

BETAMETHASONE [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QS03BA03

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

CFR

21 CFR 524.1044D

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

CFR

21 CFR 524.1044I

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ATC

R03BA04

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

CFR

21 CFR 524.1044B

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QA07EA04

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

D07AC01

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

FDA ORPHAN DRUG

492415

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

NDF-RT

N0000175576

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QD07BC01

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

D07CC01

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ATC

S01BB04

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QD07CC01

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

NDF-RT

N0000175450

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QR03BA04

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

S01CA05

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QS02CA90

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

S01CB04

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ATC

A07EA04

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ESSENTIAL MEDICINES LIST

13.3

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QS01BA06

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

H02AB01

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ATC

S01BA06

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

CFR

21 CFR 524.1044G

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QD07XC01

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QS01CB04

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QH02AB01

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

CFR

21 CFR 524.1044F

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ATC

R01AD06

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ATC

D07XC01

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QC05AA05

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

NCI_THESAURUS

C521

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

S02BA07

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QS03CA06

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

D07BC01

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

LIVERTOX

100

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QS01BB04

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

S03CA06

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-ATC

S03BA03

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QD07AC01

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QS01CA05

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-ATC

C05AA05

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

WHO-VATC

QR01AD06

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

WHO-VATC

QS02BA07

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

Code System Code Type Description

RXCUI

1514

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

RxNorm

CHEBI

3077

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

PRIMARY

MERCK INDEX

m2452

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

Merck Index

MESH

D001623

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

LACTMED

Betamethasone

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

ChEMBL

CHEMBL632

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

PRIMARY

EVMPD

SUB05797MIG

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

PRIMARY

NCI_THESAURUS

C303

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

SMS_ID

100000091947

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

BETAMETHASONE

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

Description: A white or creamy white powder; odourless. Solubility: Practically insoluble in water; sparingly soluble in ethanol (~750 g/l) TS. Category: Adrenoglucocorticoid. Storage: Betamethasone should be kept in a tightly closed container, protected from light. Definition: Betamethasone contains not less than 96.0% and not more than 104.0% of C22H29FO5 calculated with reference to the dried substance.

WIKIPEDIA

BETAMETHASONE

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

EPA CompTox

DTXSID3022667

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

HSDB

3015

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

PUBCHEM

9782

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

INN

1045

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

LACTMED

Betamethasone, Topical

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

CAS

378-44-9

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

PRIMARY

FDA UNII

9842X06Q6M

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

RS_ITEM_NUM

1066009

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

DAILYMED

9842X06Q6M

Created by admin on Fri Dec 15 15:12:58 GMT 2023 , Edited by admin on Fri Dec 15 15:12:58 GMT 2023

PRIMARY

NSC

39470

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

DRUG BANK

DB00443

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

ECHA (EC/EINECS)

206-825-4

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

DRUG CENTRAL

348

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

IUPHAR

7061

Created by admin on Fri Dec 15 15:12:59 GMT 2023 , Edited by admin on Fri Dec 15 15:12:59 GMT 2023

PRIMARY

ACTIVE MOIETY


					9842X06Q6M

BETAMETHASONE

SALT/SOLVATE (PARENT)


					E7ZY47584A

BETAMETHASONE SODIUM

Details

SMILES

InChI

DescriptionSources: https://www.drugbank.ca/drugs/DB00443

Originator

Approval Year

Targets

Conditions

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Cmax

AUC

T1/2

Funbound

Doses

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Tox targets

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.drugbank.ca/drugs/DB00443

C_max

T_1/2

F_unbound

Drug as perpetrator