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Advanced head and neck cancer

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ETANIDAZOLE

30DKA3Q1HL

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Glutathione-S-transferase

Conditions:

Advanced head and neck cancer

Etanidazole (also known as Radinyl) is a 2-nitroimidazole with radiosensitizing properties. Etanidazole exerts its therapeutic action by depleting glutathione and inhibiting glutathione S-transferase, thus enhancing the anticancer effects of radiatio...

n therapy. Etanidazole was tested in Phase III clinical trials in patients with advanced head and neck cancer, however, its development was stopped. A fluorinated etanidazole (EF5) may also be useful as an imaging agent for identification of hypoxic, drug-resistant regions of primary tumors and metastases.

ETANIDAZOLE MONOHYDRATE

0N3DVR1IMU

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Glutathione-S-transferase

Conditions:

Advanced head and neck cancer

Etanidazole (also known as Radinyl) is a 2-nitroimidazole with radiosensitizing properties. Etanidazole exerts its therapeutic action by depleting glutathione and inhibiting glutathione S-transferase, thus enhancing the anticancer effects of radiatio...

n therapy. Etanidazole was tested in Phase III clinical trials in patients with advanced head and neck cancer, however, its development was stopped. A fluorinated etanidazole (EF5) may also be useful as an imaging agent for identification of hypoxic, drug-resistant regions of primary tumors and metastases.

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