Benzanthrone (BA) is an important dye used in the manufacturing of several polycyclic vats and disperse dyes in textile industries. In several clinical studies, it has been shown that workers exposed to BA developed itching, burning sensation, erythema and hyperpigmentation of the skin, which could be an outcome of the dysregulated immune response. Chronically exposed workers complained loss of appetite, intolerance to fatty food, fatigue, weight loss, weakness and decrease in sexual activity. Recently was discovered, that benzanthrone binds to a critical component in the regulation of the BA-induced inflammation, Toll-like receptor 4, TLR4.