Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H8N2 |
| Molecular Weight | 144.1732 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=CC2=C1N=CC=C2
InChI
InChIKey=WREVVZMUNPAPOV-UHFFFAOYSA-N
InChI=1S/C9H8N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,10H2
| Molecular Formula | C9H8N2 |
| Molecular Weight | 144.1732 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| General rules for the packing of hydrogen-bonded crystals as derived from the analysis of squaric acid anions: aminoaromatic nitrogen base co-crystals. | 2001 Aug |
|
| Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment. | 2002 |
|
| Chemistry of stable iminopropadienones, RN=C=C=C=O. | 2002 Apr 19 |
|
| Triangular test applied to the clinical trial of azithromycin against relapses in Plasmodium vivax infections. | 2002 Nov 12 |
|
| Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys. | 2003 Apr |
|
| Orally effective drugs for kala-azar (visceral leishmaniasis): focus on miltefosine and sitamaquine. | 2003 Jul |
|
| A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum. | 2003 Mar 1 |
|
| 8-Quinolinamines conjugated with amino acids are exhibiting potent blood-schizontocidal antimalarial activities. | 2004 Jan 2 |
|
| Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse. | 2004 Oct 15 |
|
| Modern malaria chemoprophylaxis. | 2005 |
|
| A phase II dose-ranging study of sitamaquine for the treatment of visceral leishmaniasis in India. | 2005 Dec |
|
| Isatin-Schiff base copper(II) complexes and their influence on cellular viability. | 2005 Jul |
|
| [Therapeutic options for visceral leishmaniasis]. | 2005 Jun |
|
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
|
| In-vitro and in-vivo studies on a topical formulation of sitamaquine dihydrochloride for cutaneous leishmaniasis. | 2006 Aug |
|
| Drug development papers in PLoS Medicine: how we try to spot a winner. | 2006 Dec |
|
| 8-Aminoquinolines: future role as antiprotozoal drugs. | 2006 Dec |
|
| Novel acetoxylation and C-C coupling reactions at unactivated positions in alpha-amino acid derivatives. | 2006 Jul 20 |
|
| Visceral leishmaniasis (kala-azar): challenges ahead. | 2006 Mar |
|
| Development and validation of a stability-indicating reversed-phase high performance liquid chromatography method for NPC 1161C, a novel 8-aminoquinoline anti-malarial drug. | 2006 Mar 31 |
|
| Direct nitric oxide detection in aqueous solution by copper(II) fluorescein complexes. | 2006 Nov 8 |
|
| Self-gelling primaquine-gum arabic conjugate: an injectable controlled delivery system for primaquine. | 2007 Jan |
|
| Response to malaria epidemics in Africa. | 2007 May |
|
| Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays. | 2007 Sep 24 |
|
| Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki. | 2008 Aug |
|
| Selection of the most promising 2-substituted quinoline as antileishmanial candidate for clinical trials. | 2008 Dec |
|
| The role of anti-malarial drugs in eliminating malaria. | 2008 Dec 11 |
|
| N,N'-Bis(8-quinol-yl)pyridine-2,6-dicarboxamide. | 2008 Jan 11 |
|
| 8-Quinolylguanidinium chloride. | 2008 Jun 7 |
|
| One-dimensional hydrogen-bonded structures in the 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid with 8-hydroxyquinoline, 8-aminoquinoline and quinoline-2-carboxylic acid (quinaldic acid). | 2008 Mar |
|
| Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511). | 2008 Sep |
|
| Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines. | 2008 Sep |
|
| Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 |
|
| Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface. | 2009 Dec 15 |
|
| Palladium-catalyzed aryl C-H bonds activation/acetoxylation utilizing a bidentate system. | 2009 Dec 17 |
|
| Bis(N-triisopropyl-silyl-quinolin-8-aminato)nickel(II). | 2009 Dec 4 |
|
| N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents. | 2009 May |
|
| Electrochemistry of ruthenium(II) complexes of 8-aminoquinoline. | 2009 May 14 |
|
| Application of a liquid extraction based sealing surface sampling probe for mass spectrometric analysis of dried blood spots and mouse whole-body thin tissue sections. | 2009 Nov 1 |
|
| Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. | 2009 Nov 15 |
|
| Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging. | 2009 Nov 18 |
|
| Synthesis and characterization of organoaluminum compounds containing quinolin-8-amine derivatives and their catalytic behaviour for ring-opening polymerization of epsilon-caprolactone. | 2009 Nov 7 |
|
| Direct analysis of dried blood spots utilizing desorption electrospray ionization (DESI) mass spectrometry. | 2010 Apr |
|
| A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito. | 2010 Apr 6 |
|
| Mechanism of interaction of sitamaquine with Leishmania donovani. | 2010 Dec |
|
| The reality of using primaquine. | 2010 Dec 27 |
|
| 2,4-Dichloro-6-(8-quinolylamino-methyl-ene)cyclo-hexa-2,4-dien-1-one methanol solvate. | 2010 Jan 23 |
|
| From sensors to silencers: quinoline- and benzimidazole-sulfonamides as inhibitors for zinc proteases. | 2010 Jun 23 |
|
| Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. | 2010 Mar |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:10:38 GMT 2023
by
admin
on
Fri Dec 15 17:10:38 GMT 2023
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| Record UNII |
U34EAV21TG
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| Record Status |
Validated (UNII)
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| Record Version |
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11359
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36709
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8-AMINOQUINOLINE
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209-427-9
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U34EAV21TG
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7933
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