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Details

Stereochemistry ACHIRAL
Molecular Formula C9H8N2
Molecular Weight 144.1732
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 8-AMINOQUINOLINE

SMILES

NC1=CC=CC2=C1N=CC=C2

InChI

InChIKey=WREVVZMUNPAPOV-UHFFFAOYSA-N
InChI=1S/C9H8N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,10H2

HIDE SMILES / InChI

Molecular Formula C9H8N2
Molecular Weight 144.1732
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Modern malaria chemoprophylaxis.
2005
Evaluation of immobilized metal-ion affinity chromatography for the fractionation of natural Cu complexing ligands.
2005 Dec 30
[Therapeutic options for visceral leishmaniasis].
2005 Jun
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
A phase II dose-increasing study of sitamaquine for the treatment of visceral leishmaniasis in Kenya.
2005 Nov
Clinical status of agents being developed for leishmaniasis.
2005 Nov
In-vitro and in-vivo studies on a topical formulation of sitamaquine dihydrochloride for cutaneous leishmaniasis.
2006 Aug
8-Aminoquinolines: future role as antiprotozoal drugs.
2006 Dec
Novel acetoxylation and C-C coupling reactions at unactivated positions in alpha-amino acid derivatives.
2006 Jul 20
Visceral leishmaniasis (kala-azar): challenges ahead.
2006 Mar
Development and validation of a stability-indicating reversed-phase high performance liquid chromatography method for NPC 1161C, a novel 8-aminoquinoline anti-malarial drug.
2006 Mar 31
Direct nitric oxide detection in aqueous solution by copper(II) fluorescein complexes.
2006 Nov 8
Self-gelling primaquine-gum arabic conjugate: an injectable controlled delivery system for primaquine.
2007 Jan
DNA interaction of new copper(II) complexes with sulfonamides as ligands.
2007 Mar
Tafenoquine: a promising new antimalarial agent.
2007 May
Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays.
2007 Sep 24
Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki.
2008 Aug
Effects of amino acids on malarial heme crystallization.
2008 Aug
Selection of the most promising 2-substituted quinoline as antileishmanial candidate for clinical trials.
2008 Dec
Identification of differentially expressed genes after acute exposure to bulaquine (CDRI 80/53) in mice liver.
2008 Dec
The role of anti-malarial drugs in eliminating malaria.
2008 Dec 11
8-Quinolylguanidinium chloride.
2008 Jun 7
One-dimensional hydrogen-bonded structures in the 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid with 8-hydroxyquinoline, 8-aminoquinoline and quinoline-2-carboxylic acid (quinaldic acid).
2008 Mar
Selection and phenotype characterisation of sitamaquine-resistant promastigotes of Leishmania donovani.
2008 Mar
Electrospray ionization-ion trap mass spectrometry study of PQAAPro and PQProAA mimetic derivatives of the antimalarial primaquine.
2008 Oct
Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]- 5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511).
2008 Sep
Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines.
2008 Sep
Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin.
2009
Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives.
2009
Antimalarials and the fight against malaria in Brazil.
2009 Aug
Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface.
2009 Dec 15
Palladium-catalyzed aryl C-H bonds activation/acetoxylation utilizing a bidentate system.
2009 Dec 17
Bis(N-triisopropyl-silyl-quinolin-8-aminato)nickel(II).
2009 Dec 4
Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations.
2009 Jul 15
N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents.
2009 May
Electrochemistry of ruthenium(II) complexes of 8-aminoquinoline.
2009 May 14
Application of a liquid extraction based sealing surface sampling probe for mass spectrometric analysis of dried blood spots and mouse whole-body thin tissue sections.
2009 Nov 1
Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes.
2009 Nov 15
Synthesis and characterization of organoaluminum compounds containing quinolin-8-amine derivatives and their catalytic behaviour for ring-opening polymerization of epsilon-caprolactone.
2009 Nov 7
The synthesis and coordination chemistry of a tris-8-aminoquinoline tripodal ligand.
2009 Oct 21
Solid-phase extractors based on 8-aminoquinoline and 2-aminopyridine covalently bonded to silica gel for the selective separation and determination of calcium in natural water and pharmaceutical samples.
2010
Direct analysis of dried blood spots utilizing desorption electrospray ionization (DESI) mass spectrometry.
2010 Apr
Cascading transformations within a dynamic self-assembled system.
2010 Aug
Control of visceral leishmaniasis in latin america-a systematic review.
2010 Jan 19
2,4-Dichloro-6-(8-quinolylamino-methyl-ene)cyclo-hexa-2,4-dien-1-one methanol solvate.
2010 Jan 23
Bis[2-(8-quinolylimino-meth-yl)phenolato-κN,N',O]iron(III) azide.
2010 Jan 27
From sensors to silencers: quinoline- and benzimidazole-sulfonamides as inhibitors for zinc proteases.
2010 Jun 23
Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination.
2010 Mar
The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan.
2010 May 25
Operational strategies to achieve and maintain malaria elimination.
2010 Nov 6
Patents
Substance Class Chemical
Created
by admin
on Thu Jul 06 00:32:39 UTC 2023
Edited
by admin
on Thu Jul 06 00:32:39 UTC 2023
Record UNII
U34EAV21TG
Record Status Validated (UNII)
Record Version
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Name Type Language
8-AMINOQUINOLINE
VANDF  
Systematic Name English
NC-066
Code English
8-QUINOLINYLAMINE
Systematic Name English
8-QUINOLINAMINE
Systematic Name English
AMINOQUINOLINE, 8-
Systematic Name English
8-QUINOLYLAMINE
Systematic Name English
NSC-7933
Code English
AMINOQUINOLINE [VANDF]
Common Name English
8-AMINOQUINOLINE [VANDF]
Common Name English
QUINOLINE, 8-AMINO-
Systematic Name English
WR-6920
Code English
Code System Code Type Description
EPA CompTox
DTXSID4060369
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
PUBCHEM
11359
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
CHEBI
36709
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
WIKIPEDIA
8-AMINOQUINOLINE
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
ECHA (EC/EINECS)
209-427-9
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
CAS
578-66-5
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
FDA UNII
U34EAV21TG
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
NSC
7933
Created by admin on Thu Jul 06 00:32:39 UTC 2023 , Edited by admin on Thu Jul 06 00:32:39 UTC 2023
PRIMARY
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