U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 71 - 80 of 411 results

Status:
Possibly Marketed Outside US
Source:
Pet MD Chlorhexidine Wipes XL by Pet MD Brands, LLC
(2017)
Source URL:
First approved in 2017
Source:
Pet MD Chlorhexidine Wipes XL by Pet MD Brands, LLC
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

4-n-octylphenol is alkylphenol widely used as a surfactant. 4-n-octylphenol exposure was associated with idiopathic male infertility. Fetal exposure to the very weak estrogenicity of 4-n-octylphenol could enhance the induction of mammary carcinomas but not affect the induction of benign proliferative lesions. It is an endocrine-disrupting chemical. 4-n-octylphenol is an agonist and antagonist of estrogen receptor and androgen receptor, respectively. 4-n-octylphenol at high doses caused reduction in mammary tumor development in female human c-Ha-ras proto-oncogene transgenic rats and possibly non-transgenic rats.