U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Showing 1 - 10 of 61 results

Status:
US Approved Rx (2004)
First approved in 1970

Class (Stereo):
CHEMICAL (ACHIRAL)



Flavoxate is a drug, indicated for symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis. Flavoxate is not indicated for defi...
Status:
US Approved Rx (2019)
First approved in 1970

Class (Stereo):
CHEMICAL (ABSOLUTE)



Levodopa (L-DOPA) was first isolated from seedlings of Vicia faba by Marcus Guggenheim in 1913. Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement agent used to treat Parkinson's disease. Oral levodopa has been wi...
Status:
US Approved Rx (2001)
First approved in 1970

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Ketamine (brand name Ketalar) is a cyclohexanone derivative used for induction of anesthesia. Ketalar is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation; also, it is indicat...
Status:
US Approved Rx (2017)
First approved in 1970

Class (Stereo):
CHEMICAL (ABSOLUTE)



Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin. Clindamycin inhibits bacterial...
Status:
US Approved Rx (1989)
First approved in 1970

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Flurazepam (known under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM). Furthermore, it decreases sle...
Status:
US Approved Rx (1970)
First approved in 1970

Class (Stereo):
CHEMICAL (RACEMIC)



Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inh...
Status:
US Approved Rx (2019)
First approved in 1970

Class (Stereo):
CHEMICAL (ABSOLUTE)

Esketamine is an S(+)-enantiomer of ketamine. It is a nonselective, noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor. A nasal spray, containing esketamine, was approved in 2019 for the treatment of treatment-resistant depression in a...
Status:
US Approved Rx (2001)
First approved in 1970

Class (Stereo):
CHEMICAL (ABSOLUTE)



Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents no...
Status:
US Approved Rx (2020)
First approved in 1970

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Penicillamine, sold under the trade names of Cuprimine among others, is a medication primarily used for treatment of Wilson's disease, cystinuria and active rheumatoid arthritis. Penicillamine is a chelating agent recommended for the removal of exces...
Status:
US Previously Marketed
First approved in 1970

Class (Stereo):
CHEMICAL (MIXED)



Mesoridazine (brand name Serentil) is a phenothiazine antipsychotic. It was marketed in the U.S. for the treatment of schizophrenia, behavioral problems in mental deficiency and chronic brain syndrome, alcoholism and psychoneurotic symptoms, such as ...