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Status:
Possibly Marketed Outside US
Source:
21 CFR 358A
(1964)
Source URL:
First approved in 1964
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
M012
(2021)
Source URL:
First approved in 1964
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Propyl Gallate is the n-propyl ester of gallic acid (3,4,5-trihydroxybenzoic acid). It is soluble in ethanol, ethyl ether, oil, lard, and aqueous solutions of polyethylene glycol (PEG) ethers of cetyl alcohol, but only slightly soluble in water. Propyl Gallate currently is used as an antioxidant in a reported 167 cosmetic products at maximum concentrations of 0.1%. Propyl Gallate is a generally recognized as safe (GRAS) antioxidant to protect fats, oils, and fat-containing food from rancidity that results from the formation of peroxides. The biological activity of Propyl Gallate is consistent with its free-radical scavenging ability, with effects that include antimicrobial activity, enzyme inhibition, inhibition of biosynthetic processes, inhibition of the formation of nitrosamines, anesthesia, inhibition of neuromuscular response to chemicals, ionizing/ultraviolet (UV) radiation protection, chemoprotection, antimutagenesis, anticarcinogenesis and antitumorigenesis, antiteratogenesis, and anticariogenesis. Propyl gallate has being shown to be a hepatoprotector in vitro and in vivo.
Status:
US Previously Marketed
Source:
VANOBID by SANOFI AVENTIS US
(1982)
Source URL:
First approved in 1964
Class:
MIXTURE
Targets:
Conditions:
This bioactive compound was named candicidin, because of its high activity on Candida albicans. Candicidin is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis. Candicidin inhibits cell membrane of Candida albicans, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
Status:
US Previously Marketed
First approved in 1964
Source:
VIRAC REX by CHESEBROUGH PONDS
Source URL:
Class:
MIXTURE
Conditions:
Formed as a complex of iodine with undecoylium chloride, undecoylium chloride iodine is a cationic detergent typically used as a topical antigermicidal agent.
Status:
Possibly Marketed Outside US
First approved in 1964
Source:
Stop-A-Leak by H. W. Naylor Company Inc.
Source URL:
Class:
MIXTURE
Status:
Possibly Marketed Outside US
Source:
NDA208552
(1964)
Source URL:
First approved in 1964
Source:
NDA208552
Source URL:
Class:
MIXTURE
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2016)
Source URL:
First approved in 1964
Source:
NDA208552
Source URL:
Class:
MIXTURE
Status:
US Approved Rx
(2020)
Source:
ANDA209599
(2020)
Source URL:
First approved in 1964
Class:
POLYMER
Status:
Possibly Marketed Outside US
Source:
21 CFR 346
(1964)
Source URL:
First approved in 1964
Source:
21 CFR 346
Source URL:
Class:
POLYMER
Status:
US Approved OTC
Source:
21 CFR 347.10(d) skin protectant cocoa butter
Source URL:
First approved in 1964
Source:
21 CFR 346
Source URL:
Class:
STRUCTURALLY DIVERSE