U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 31 - 40 of 102 results

Propyl Gallate is the n-propyl ester of gallic acid (3,4,5-trihydroxybenzoic acid). It is soluble in ethanol, ethyl ether, oil, lard, and aqueous solutions of polyethylene glycol (PEG) ethers of cetyl alcohol, but only slightly soluble in water. Propyl Gallate currently is used as an antioxidant in a reported 167 cosmetic products at maximum concentrations of 0.1%. Propyl Gallate is a generally recognized as safe (GRAS) antioxidant to protect fats, oils, and fat-containing food from rancidity that results from the formation of peroxides. The biological activity of Propyl Gallate is consistent with its free-radical scavenging ability, with effects that include antimicrobial activity, enzyme inhibition, inhibition of biosynthetic processes, inhibition of the formation of nitrosamines, anesthesia, inhibition of neuromuscular response to chemicals, ionizing/ultraviolet (UV) radiation protection, chemoprotection, antimutagenesis, anticarcinogenesis and antitumorigenesis, antiteratogenesis, and anticariogenesis. Propyl gallate has being shown to be a hepatoprotector in vitro and in vivo.
mixture
Status:
US Previously Marketed
First approved in 1964
Source:
Candeptin by Julius Schmid
Source URL:

Class:
MIXTURE



This bioactive compound was named candicidin, because of its high activity on Candida albicans. Candicidin is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis. Candicidin inhibits cell membrane of Candida albicans, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
mixture
Status:
US Previously Marketed
Source:
Softcon Bandage Lens by American Optical
(1973)
Source URL:
First approved in 1964

Class:
MIXTURE

Conditions:

Formed as a complex of iodine with undecoylium chloride, undecoylium chloride iodine is a cationic detergent typically used as a topical antigermicidal agent.
mixture
Status:
Possibly Marketed Outside US
Source:
Canada:ETHYL CELLULOSE
Source URL:
First approved in 1964
Source:
Stop-A-Leak by H. W. Naylor Company Inc.
Source URL:

Class:
MIXTURE

Status:
First approved in 1964
Source:
Cuemid by Merck Sharp & Dohme
Source URL:

Class:
POLYMER

structurally diverse
Status:
US Approved OTC
Source:
21 CFR 347.10(d) skin protectant cocoa butter
Source URL:

Class:
STRUCTURALLY DIVERSE