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Description
Curator's Comment: description was created based on several sources, including: http://www.ncbi.nlm.nih.gov/pubmed/773298

This bioactive compound was named candicidin, because of its high activity on Candida albicans. Candicidin is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis. Candicidin inhibits cell membrane of Candida albicans, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.

Originator

Curator's Comment: The first in vivo evaluation of candicidin was made by Kligman & Lewis in 1953. It was found to protect mice infected with Candida albicans, Blastomyces dermatitidis, and Sporotrichum schenckii, but had only a partial protective effect on torulosis and histoplasmosis in mice.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
VANOBID

Approved Use

Candicidin
PubMed

PubMed

TitleDatePubMed
Candicidin and other polyenic antifungal antibiotics.
1965
Mode of action of the polyene antibiotic candicidin: binding factors in the wall of Candida albicans.
1976 Apr
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Vaginal
In Vitro Use Guide
Candicidin inhibits the growth of a large number of fungi. It inhibits Candida species with 0.5 ug/ml to 50 ug/ml
Substance Class Mixture
Created
by admin
on Sat Dec 16 10:44:15 GMT 2023
Edited
by admin
on Sat Dec 16 10:44:15 GMT 2023
Record UNII
48N2IYJ202
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Candicidin
INN   MART.   MI   ORANGE BOOK   USAN   WHO-DD  
INN   USAN  
Official Name English
levorin [INN]
Common Name English
candicidin [INN]
Common Name English
CANDICIDIN [USAN]
Common Name English
Candicidin [WHO-DD]
Common Name English
CANDICIDIN [MART.]
Common Name English
NSC-94219
Code English
NSC-759868
Code English
LEVORIN
INN  
Official Name English
CANDICIDIN [ORANGE BOOK]
Common Name English
Levorin [WHO-DD]
Common Name English
VANOBID
Brand Name English
CANDICIDIN [MI]
Common Name English
G01AA04
Code English
ASCOSIN
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C258
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
WHO-VATC QG01AA04
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
WHO-ATC G01AA04
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
Code System Code Type Description
NSC
94219
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
INN
2013
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PRIMARY
NCI_THESAURUS
C87461
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PRIMARY
EPA CompTox
DTXSID301014435
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
WIKIPEDIA
CANDICIDIN
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
ChEMBL
CHEMBL2108379
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PRIMARY
FDA UNII
48N2IYJ202
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PRIMARY
CAS
11014-70-3
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
ALTERNATIVE
MESH
D002174
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PRIMARY
MERCK INDEX
m3013
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY Merck Index
CAS
1402-88-6
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
ALTERNATIVE
DRUG CENTRAL
4424
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PRIMARY
ECHA (EC/EINECS)
215-763-7
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PRIMARY
DRUG BANK
DB01152
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PRIMARY
CAS
1403-17-4
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
NSC
759868
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
EVMPD
SUB01021MIG
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200647
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
CHEBI
354984
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
INN
1822
Created by admin on Sat Dec 16 10:44:15 GMT 2023 , Edited by admin on Sat Dec 16 10:44:15 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY
Definition References