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Approval Year

1895

3

Unknown

139,593

1921

1,467

2020

742

2013

596

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Development Status

US Approved OTC

2

US Previously Marketed

1

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Primary Target

Sodium channel protein type 10 subunit alpha

2

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Highest Phase

Approved

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Condition

Burn

2

Canker sores

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Hemorrhoids

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Otitis media

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Sore mouth

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Treatment Modality

Palliative

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Originator

Ritsert, E

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Chemical

3

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CAS

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EPA CompTox

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NCI_THESAURUS

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ATC Level 1

CARDIOVASCULAR SYSTEM

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DERMATOLOGICALS

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NERVOUS SYSTEM

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RESPIRATORY SYSTEM

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ATC Level 2

ANESTHETICS

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ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.

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THROAT PREPARATIONS

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VASOPROTECTIVES

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ATC Level 3

AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE

1

ANESTHETICS, LOCAL

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ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.

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THROAT PREPARATIONS

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ATC Level 4

Anesthetics for topical use

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Anesthetics, local

1

Esters of aminobenzoic acid

1

Local anesthetics

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Principal Form

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BENZOCAINE

U3RSY48JW5

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Status:

US Approved OTC

First marketed in 1895

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel protein type 10 subunit alpha

Conditions:

Benzocaine is a local anesthetic. It acts by blocking voltage-gated sodium ion channels in nerve endings. Benzocaine is available over-the counter for local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, to...

othache, sore gums, denture irritation), otic pain, and as a local anesthetic for surgical or diagnostic procedures. As a spray, benzocaine is used for temporary relief of pain and itching associated with minor burns, sunburn, minor cuts or scrapes, insect bites, or minor skin irritations. Topical application of benzocaine to gums or mouth may cause rare, but serious and potentially fatal adverse effect methemoglobinemia.

SULFONETHYLMETHANE

217727W28W

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Status:

US Previously Marketed

First marketed in 1895

Class (Stereo):

CHEMICAL (ACHIRAL)

BENZOCAINE HYDROCHLORIDE

OG625Z9LEO

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Search for Structure

Status:

US Approved OTC

First marketed in 1895

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel protein type 10 subunit alpha

Conditions:

Benzocaine is a local anesthetic. It acts by blocking voltage-gated sodium ion channels in nerve endings. Benzocaine is available over-the counter for local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, to...

othache, sore gums, denture irritation), otic pain, and as a local anesthetic for surgical or diagnostic procedures. As a spray, benzocaine is used for temporary relief of pain and itching associated with minor burns, sunburn, minor cuts or scrapes, insect bites, or minor skin irritations. Topical application of benzocaine to gums or mouth may cause rare, but serious and potentially fatal adverse effect methemoglobinemia.

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