Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H15N3S |
| Molecular Weight | 161.268 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCCSC(N)=N
InChI
InChIKey=OLHQOJYVQUNWPL-UHFFFAOYSA-N
InChI=1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)
| Molecular Formula | C6H15N3S |
| Molecular Weight | 161.268 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25524412 | https://www.ncbi.nlm.nih.gov/pubmed/21211106
Curator's Comment: Dimaprit is CNS active in animals. No human data available.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937. | 1997 Jun |
|
| Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment. | 2001 Feb |
|
| Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum. | 2001 Jul |
|
| Cloning and characterization of a novel human histamine receptor. | 2001 Mar |
|
| Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. | 2001 Mar 15 |
|
| Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. | 2001 May 4 |
|
| Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-receptors. | 2001 Sep |
|
| Activation of histamine H2 receptors ameliorates experimental allergic encephalomyelitis. | 2002 Aug 7 |
|
| Characteristics of histamine tachyphylaxis in rat uterine smooth muscle. | 2002 Dec |
|
| Further evidence for the involvement of histamine H2 receptors in the control of defensive behaviour generated in the midbrain tectum. | 2002 Feb |
|
| Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. | 2002 Oct |
|
| Histamine receptor type coupled to nitric oxide-induced relaxation of guinea-pig nasal mucosa. | 2002 Oct-Dec |
|
| Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18. | 2002 Sep 27 |
|
| Differential activation of dual signaling responses by human H1 and H2 histamine receptors. | 2003 Feb |
|
| PD-136,450: a CCK2 (gastrin) receptor antagonist with antisecretory, anxiolytic and antiulcer activity. | 2003 Oct |
|
| Replacement of amino acid sequence features of a- and c-subunits of ATP synthases of Alkaliphilic Bacillus with the Bacillus consensus sequence results in defective oxidative phosphorylation and non-fermentative growth at pH 10.5. | 2004 Jun 18 |
|
| Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. | 2005 Dec |
|
| Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro. | 2005 Nov |
|
| Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. | 2006 Apr |
|
| Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism. | 2006 Jul |
|
| Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. | 2007 Jun |
|
| Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats. | 2007 Sep |
|
| The ATPase cycle of the mitochondrial Hsp90 analog Trap1. | 2008 Apr 25 |
|
| Validation of a conscious rat model for the discovery of novel agents that inhibit gastric acid secretion. | 2008 Jul 28 |
|
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | 2008 Jun 6 |
Patents
Sample Use Guides
In vitro, dimaprit dose dependently inhibited the production of TNF-alpha in mouse peritoneal macrophages and human peripheral blood monocytes stimulated with lipopolysaccharide with IC50 values of 1 uM.
Dimaprit, added to tumour cell cultures (100 uM), inhibited the incorporation of 3H-thymidine while embryonic cell cultures were unaffected.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:45:56 GMT 2023
by
admin
on
Fri Dec 15 19:45:56 GMT 2023
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| Record UNII |
ZZQ699148P
|
| Record Status |
Validated (UNII)
|
| Record Version |
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| Code System | Code | Type | Description | ||
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DIMAPRIT
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65119-89-3
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DTXSID0037154
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ZZQ699148P
Created by
admin on Fri Dec 15 19:45:56 GMT 2023 , Edited by admin on Fri Dec 15 19:45:56 GMT 2023
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3077
Created by
admin on Fri Dec 15 19:45:56 GMT 2023 , Edited by admin on Fri Dec 15 19:45:56 GMT 2023
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