SULFATROXAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H13N3O3S
Molecular Weight	267.304
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C)C(NS(=O)(=O)C2=CC=C(N)C=C2)=NO1

InChI

InChIKey=DAUFGBIKKGOPJA-UHFFFAOYSA-N

InChI=1S/C11H13N3O3S/c1-7-8(2)17-13-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula	C11H13N3O3S
Molecular Weight	267.304
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3730524 | https://www.ncbi.nlm.nih.gov/pubmed/3393735 | https://www.ncbi.nlm.nih.gov/pubmed/7998695

Sulfatroxazole is a sulfamide derivative patented by Swiss multinational healthcare company F. Hoffmann-La Roche & Co., A.-G. as an antibacterial agent and bacteriostatic antibiotic. Sulfatroxazole competitively inhibits dihydropteroate synthase preventing the formation of dihydropteroic acid, a precursor of folic acid which is required for bacterial growth. Sulfatroxazole is a component present in various veterinary drugs.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Endothelin receptor ET-A 19 Target ID: CHEMBL4566 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7861414\|https://www.ncbi.nlm.nih.gov/pubmed/7731020	Antagonist 2778		260.0 nM [IC50]
Bacteria 7 Target ID: CHEMBL612490 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3701916	Inhibitor 8297

PubMed

Title	Date	PubMed
Pharmacokinetics, metabolism and renal excretion of sulfatroxazole and its 5-hydroxy- and N4-acetyl-metabolites in man.	1986 May-Jun	3730524

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:15:13 GMT 2023` Edited by `admin` on `Fri Dec 15 19:15:13 GMT 2023`
Record UNII	ZXC0PT8FFS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFATROXAZOLE

Official Name

English

sulfatroxazole [INN]

Common Name

English

N(SUP 1)-(4,5-DIMETHYL-3-ISOXAZOLYL)SULFANILAMIDE

Systematic Name

English

SULFATROXAZOLE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QJ01EW14