Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H39NO |
| Molecular Weight | 285.5084 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCC[C@@H](O)[C@H](C)N
InChI
InChIKey=YRYJJIXWWQLGGV-ZWKOTPCHSA-N
InChI=1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18+/m0/s1
| Molecular Formula | C18H39NO |
| Molecular Weight | 285.5084 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Deoxysphingoid bases as plasma markers in diabetes mellitus. | 2010-08-16 |
|
| Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors. | 2009-06 |
|
| Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. | 2008-08 |
|
| Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. | 2008-04-28 |
|
| Compatibility and stability of the novel anticancer agent ES-285 x HCl formulated with 2-hydroxypropyl-beta-cyclodextrin in infusion devices. | 2006-01 |
|
| Kahalalide F and ES285: potent anticancer agents from marine molluscs. | 2006 |
|
| Pharmaceutical development of a parenteral lyophilised formulation of the investigational anticancer agent ES-285.HCl. | 2005-10-13 |
|
| Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285 x HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form. | 2003-12-12 |
|
| Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate. | 2003-10-03 |
|
| Phenylisothiocyanate and dansyl chloride precolumn derivatizations for the high-performance liquid chromatography analysis of the antitumoral agent ES-285 in dog plasma. | 2003-07-05 |
|
| Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry. | 2003-05 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:52:04 GMT 2025
by
admin
on
Mon Mar 31 21:52:04 GMT 2025
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| Record UNII |
ZX5D253CYY
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| Record Status |
Validated (UNII)
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| Record Version |
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