KP-1212

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H14N4O4
Molecular Weight	230.2212
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC(=O)N(CN1)[C@H]2C[C@H](O)[C@@H](CO)O2

InChI

InChIKey=LAOLDMMWVYDDID-KVQBGUIXSA-N

InChI=1S/C8H14N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h4-6,13-14H,1-3H2,(H3,9,10,11,15)/t4-,5+,6+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C8H14N4O4
Molecular Weight	230.2212
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:31:33 GMT 2025` Edited by `admin` on `Tue Apr 01 16:31:33 GMT 2025`
Record UNII	ZV3RS7MHH7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

KP-1212

Code

English

KP1212

Preferred Name

English

1,3,5-TRIAZIN-2(1H)-ONE, 4-AMINO-1-(2-DEOXY-.BETA.-D-ERYTHRO-PENTOFURANOSYL)-3,6-DIHYDRO-

Systematic Name

English

SN-1212

Code

English

6-AMINO-3-((2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-1,2-DIHYDRO-1,3,5-TRIAZIN-4-ONE

Systematic Name

English

4-AMINO-1-(2-DEOXY-.BETA.-D-ERYTHRO-PENTOFURANOSYL)-3,6-DIHYDRO-1,3,5-TRIAZIN-2(1H)-ONE

Systematic Name

English

DHDAC

Common Name

English

2'-DEOXY-5,6-DIHYDRO-5-AZACYTIDINE

Common Name

English

Code System Code Type Description

CAS

114522-16-6

Created by admin on Tue Apr 01 16:31:33 GMT 2025 , Edited by admin on Tue Apr 01 16:31:33 GMT 2025

PRIMARY

PUBCHEM

9859433

Created by admin on Tue Apr 01 16:31:33 GMT 2025 , Edited by admin on Tue Apr 01 16:31:33 GMT 2025

PRIMARY

FDA UNII

ZV3RS7MHH7

Created by admin on Tue Apr 01 16:31:33 GMT 2025 , Edited by admin on Tue Apr 01 16:31:33 GMT 2025

PRIMARY

Related Record Type Details


					ZV3RS7MHH7

KP-1212

ACTIVE MOIETY

Comments:

This nucleoside (KP-1212) is not a chain terminator but exerts its antiviral effects via mutagenesis of the viral genome. Serial passaging of HIV in the presence of KP-1212 causes an increase in the mutation rate of the virus leading to viral ablation. HIV strains resistant to KP-1212 have not yet been isolated. Quite to the contrary, virus treated with KP-1212 exhibited an increased sensitivity not only to KP-1212 but also to another nucleoside reverse transcriptase inhibitor (NRTI), zidovudine.


					ZV3RS7MHH7

KP-1212

ACTIVE MOIETY

Comments:

Specifically, KP1212 is a mutagenic deoxycytidine analog that elevates the G to A mutations in viral genome shown by clinical studies. It was hypothesized that the mutation originates from the tautomerization of KP1212 from the canonical amino-keto form to the imino-keto form, which results in favorable base pairing to A.