Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H24ClN3O2.ClH |
Molecular Weight | 410.337 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)NC2CCN(CC3=CC=CC=C3)CC2
InChI
InChIKey=YFLOJFUMBVJTRZ-UHFFFAOYSA-N
InChI=1S/C20H24ClN3O2.ClH/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14;/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25);1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C20H24ClN3O2 |
Molecular Weight | 373.876 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Clebopride is a dopamine antagonist drug. It is used to treat functional gastrointestinal disorder such as nausea or vomiting. Unchanged parent drug was the most abundant compound in human urine. Major metabolites included the hydroxylation at benzyl group to yield carbinolamine and its further N-dealkylation product, and the piperidine ring hydroxylation/oxidation metabolite (a lactam).
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14871277 |
2.0 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | CLEBOPRIDE Approved UseClebopride is used in the treatment of stomach ulcer, inflammation of stomach and intestine, indigestion. It also reduces the symptoms like excessive air accumulation in gut, nausea and vomiting associated with stomach discomfort. |
PubMed
Title | Date | PubMed |
---|---|---|
NMDA receptor antagonists inhibit catalepsy induced by either dopamine D1 or D2 receptor antagonists. | 1993 Jun 11 |
|
Dopamine antagonists during parturition disrupt maternal care and the retention of maternal behavior in rats. | 2002 Nov |
|
Acute oculogyric crisis in a patient taking clebopride. | 2008 |
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Acute hemifacial dystonia possibly induced by clebopride. | 2009 Mar-Apr |
|
Development and validation of a LC-MS/MS method for the determination of clebopride and its application to a pharmacokinetics study in healthy Chinese volunteers. | 2010 Aug 1 |
|
A randomized, controlled, double-blind trial of the adjunct use of Clebopride in polyethylene glycol electrolyte (PEG) solution for colonoscopy preparation. | 2010 Jan |
|
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17365143
Clebopride at 10 uM significantly decreased the Vmax of phase 0 depolarization in isolated rabbit Purkinje fiber and significantly prolonged the action potential duration at 90% repolarization, whereas the action potential duration at 50% repolarization was not prolonged. For hERG potassium channel currents in human ether-à-go-go-related gene (hERG)-stably transfected Chinese hamster ovarian (CHO) cells the IC50 value was 0.62 uM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 04:54:23 UTC 2023
by
admin
on
Sat Dec 16 04:54:23 UTC 2023
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Record UNII |
ZU312V0958
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Record Status |
Validated (UNII)
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Record Version |
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3044762
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57645-39-3
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64877-77-6
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DTXSID10206339
Created by
admin on Sat Dec 16 04:54:23 UTC 2023 , Edited by admin on Sat Dec 16 04:54:23 UTC 2023
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SOLVATE->ANHYDROUS |
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ACTIVE MOIETY |