Greziprubart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:29:47 GMT 2025` Edited by `admin` on `Wed Apr 02 13:29:47 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	ZQL8925JUB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Greziprubart

Official Name

English

STSA-1002

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens C5 (complement 5) anaphylatoxin (C5a, C5 Pr678-751)], Homo sapiens monoclonal antibody

Common Name

English

H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3-72*01 (88.8%) -(IGHD) -IGHJ5*01 (91.7%) T122>V (113), CDR-IMGT [8.10.10] (26-33.51-60.99-108)) (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v14 CH2 A1.3, A1

Common Name

English

Immunoglobulin G1 [236-alanine,237-alanine], anti-(human complement C5a) (human monoclonal STSA-1002 ?1-chain), disulfide with human monoclonal STSA-1002 ?-chain, dimer

Common Name

English

greziprubart [INN]

Common Name

English

Code System Code Type Description

FDA UNII

ZQL8925JUB

Created by admin on Wed Apr 02 13:29:47 GMT 2025 , Edited by admin on Wed Apr 02 13:29:47 GMT 2025

PRIMARY

CAS

2894136-80-0

Created by admin on Wed Apr 02 13:29:47 GMT 2025 , Edited by admin on Wed Apr 02 13:29:47 GMT 2025

PRIMARY

INN

13120

Created by admin on Wed Apr 02 13:29:47 GMT 2025 , Edited by admin on Wed Apr 02 13:29:47 GMT 2025

PRIMARY

NCI_THESAURUS

C211833

Created by admin on Wed Apr 02 13:29:47 GMT 2025 , Edited by admin on Wed Apr 02 13:29:47 GMT 2025

PRIMARY

SMS_ID

300000056815

Created by admin on Wed Apr 02 13:29:47 GMT 2025 , Edited by admin on Wed Apr 02 13:29:47 GMT 2025

PRIMARY

From	To
1_22	1_98
2_22	2_98
2_146	2_202
2_222	4_219
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_222	3_219
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					O73AZS73V4

C5A ANAPHYLATOXIN

TARGET->LIGAND

Interaction Type:

IN-VITRO

Amount:


					O73AZS73V4

C5A ANAPHYLATOXIN

TARGET -> INHIBITOR

Interaction Type:

IN-VITRO

Amount:

Related Record Type Details


					ZQL8925JUB

ACTIVE MOIETY

Interaction Type:

PRECLINICAL

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL