CIMATEROL

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H17N3O
Molecular Weight	219.2829
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NCC(O)C1=CC(C#N)=C(N)C=C1

InChI

InChIKey=BUXRLJCGHZZYNE-UHFFFAOYSA-N

InChI=1S/C12H17N3O/c1-8(2)15-7-12(16)9-3-4-11(14)10(5-9)6-13/h3-5,8,12,15-16H,7,14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C12H17N3O
Molecular Weight	219.2829
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23614528 | http://www.whatsteroids.com/cimaterol

Cimaterol is a chemically stable nonselective agonist β1-, β2-, and β3-adrenoceptors. Cimaterol is used in sport as a stimulant and a fat burner that assists bodybuilders and strength athletes to get rid of body fats. Aside from shedding off fats, another benefit for using cimaterol for athletes is a boost in strength as well as an increase in muscle size or lean body mass. The increase in muscle size has been seen in previous animal studies when cimaterol is used. However, the reason behind the muscle gain is not identified yet, but the body has a very different response compared from taking in anabolic steroids. Experts in the field are saying that the increased nitrogen retention, that is known to cause by cimaterol, maybe the reason behind the muscle gain. Another great thing about Cimaterol is that, it can improve blood flow.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Beta-3 adrenergic receptor 49 Target ID: P13945 Gene ID: 155.0 Gene Symbol: ADRB3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/23614528	Agonist 2678	6.62 null [pEC50]
Beta-1 adrenergic receptor 158 Target ID: P08588 Gene ID: 153.0 Gene Symbol: ADRB1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/23614528	Agonist 2678	8.13 null [pEC50]
Beta-2 adrenergic receptor 203 Target ID: P07550\|\|\|Q53GA6\|\|\|Q9UCZ3 Gene ID: 154.0 Gene Symbol: ADRB2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/23614528	Agonist 2678	8.78 null [pEC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Determination of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry.	2005 Jan-Feb	15759725
Field-amplified on-line sample stacking for separation and determination of cimaterol, clenbuterol and salbutamol using capillary electrophoresis.	2006 Aug 25	16828108
Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.	2007 Aug	17629959
Evaluation of the illegal use of clenbuterol in Portuguese cattle farms from drinking water, urine, hair and feed samples.	2009 Jun	19680955
Regression-based approach for testing the association between multi-region haplotype configuration and complex trait.	2009 Sep 17	19761592
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.	2010 Apr	20155493
[Determination of fifteen beta-agonists in animal urine by high performance liquid chromatography-tandem mass spectrometry].	2010 Aug	21261043
Protein microarray: sensitive and effective immunodetection for drug residues.	2010 Feb 16	20158905
A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors.	2010 Nov 30	21152092

Patents

Sample Use Guides

In Vivo Use Guide

bodybuilders and strength athletes: Both oral and injectable variants are available for cimaterol. The injectable is subcutaneously administered. Effective dosage, based on research and study, is approximately 0.15 milligram per kilogram, for both male and female. With this dosage, users can have beneficial gains from the drug for subcutaneously administered. New users of this drug are advised to start at the low-end of the spectrum to minimize the unbearable or dangerous side effects.

Route of Administration: Other

In Vitro Use Guide

H-cAMP accumulation in response to cimaterol in CHO β1 cells, CHO β2 cells, and CHO β3 cells were meacured. Cimaterol stimulated responses were 96.9 ± 1.1% (log EC50 = −8.13 ± 0.03, n = 9), 98.9 ± 1.7% (log EC50 = −8.78 ± 0.06, n = 9), and 89.6 ± 1.9% (log EC50 = −6.62 ± 0.06, n = 9) of the isoprenaline maximum response at the human β1-, β2-, and β3-adrenoceptors, respectively

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:31:17 GMT 2023` Edited by `admin` on `Fri Dec 15 16:31:17 GMT 2023`
Record UNII	ZPY8VRF0GB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CIMATEROL

Official Name

English

CIMATEROL [MI]

Common Name

English

AB-A 66

Code

English

cimaterol [INN]

Common Name

English

CIMATEROL [USAN]

Common Name

English

AB-A 663

Code

English

AB-A-66

Code

English

AC-263780

Code

English

AC 263,780

Code

English

ABA-663

Code

English

BENZONITRILE, 2-AMINO-5-(1-HYDROXY-2-((1-METHYLETHYL)AMINO)ETHYL)-, (±)-

Systematic Name

English

(±)-5-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)ANTHRANILONITRILE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C48149