ROKITAMYCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C42H69NO15
Molecular Weight	827.995
Optical Activity	UNSPECIFIED
Defined Stereocenters	16 / 16
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC(=O)O[C@H]1[C@H](C)O[C@H](C[C@@]1(C)OC(=O)CC)O[C@@H]2[C@@H](C)O[C@@H](O[C@H]3[C@@H](CC=O)C[C@@H](C)[C@@H](O)\C=C\C=C\C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]3OC)[C@H](O)[C@H]2N(C)C

InChI

InChIKey=VYWWNRMSAPEJLS-MDWYKHENSA-N

InChI=1S/C42H69NO15/c1-11-16-32(48)55-40-27(6)53-34(23-42(40,7)58-31(47)12-2)56-37-26(5)54-41(36(50)35(37)43(8)9)57-38-28(19-20-44)21-24(3)29(45)18-15-13-14-17-25(4)52-33(49)22-30(46)39(38)51-10/h13-15,18,20,24-30,34-41,45-46,50H,11-12,16-17,19,21-23H2,1-10H3/b14-13+,18-15+/t24-,25-,26-,27+,28+,29+,30-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C42H69NO15
Molecular Weight	827.995
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	16 / 16
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/8478265
Curator's Comment: description was created based on several sources, including http://www.antimicrobe.org/drugpopup/rokitamycin.htm

Rokitamycin is a macrolide antibiotic against Gram-positive bacteria. Synthesized from strains of Streptomyces kitasatoensis. Rokitamycin is an inhibitor of protein synthesis by specifically binding to the 50 S subunit of the ribosome. Specificity towards prokaryotes relies upon the absence of 50S ribosomes in eukaryotes.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial 70S ribosome 179 Target ID: CHEMBL2363135 Sources: http://www.ncbi.nlm.nih.gov/pubmed/8478265	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gram-positive bacterial infections 8 Sources: http://www.antimicrobe.org/drugpopup/rokitamycin.htm	Curative		Approved 8429	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Inhibitory and bactericidal activity of rokitamycin against Helicobacter pylori and morphological alterations.	1996 Dec	8981182

Patents

Sample Use Guides

In Vivo Use Guide

Oral granules: 10g Susceptible infections: 400mg every 12 hours for 7-14 days Oral tablet: 400mg

Route of Administration: Oral

In Vitro Use Guide

Rokitamycin killed more rapidly than the other antibiotics, in fact H. pylori strains were totally killed at 8 h (2 x MIC) and 4 h (4 x MIC) and after only 2 h incubation all concentrations greatly decreased the CFU/ml

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:36:28 GMT 2023` Edited by `admin` on `Sat Dec 16 17:36:28 GMT 2023`
Record UNII	ZPT03UEM0E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ROKITAMYCIN

Official Name

English

TMS-19Q

Code

English

3''-PROPIONYLLEUCOMYCIN A5

Common Name

English

ROKITAMYCIN [MART.]

Common Name

English

RICAMYCIN

Common Name

English

LEUCOMYCIN V, 4B-BUTANOATE 3B-PROPANOATE

Common Name

English

ROKITAMYCIN [JAN]

Common Name

English

Rokitamycin [WHO-DD]

Common Name

English

TMS 19Q

Code

English

rokitamycin [INN]

Common Name

English

ROKITAMYCIN [MI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

J01FA12