COBALTOUS CHLORIDE CO-57

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Cl.Co
Molecular Weight	127.842
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].[Cl-].[57Co++]

InChI

InChIKey=GVPFVAHMJGGAJG-HPBINRSPSA-L

InChI=1S/2ClH.Co/h2*1H;/q;;+2/p-2/i;;1-2

HIDE SMILES / InChI

Molecular Formula	Co
Molecular Weight	56.936296235
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=016089 | https://www.drugs.com/pro/rubratope-57.html | https://www.ncbi.nlm.nih.gov/pubmed/29999735 | https://www.govinfo.gov/content/pkg/FR-2017-06-21/html/2017-12908.htm

Cobaltous chloride CO-57 (or Cobalt 57) is a radioactive compound, decays by electron capture with a physical half-life of 270.9 days. This compound is a part of diagnostic capsules Rubratrope-57, for the diagnosis of pernicious anemia and as a diagnostic adjunct in other defects of intestinal vitamin B12 absorption. Rubratrope-57 was withdrawn in July 2017.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pernicious anemia 8 Sources: https://www.drugs.com/pro/rubratope-57.html#s-34067-9	Diagnostic		Approved 8583	RUBRATOPE-57 Approved Use Rubratope-57 (Cyanocobalamin Co 57 Capsules) is intended for the diagnosis of pernicious anemia and as a diagnostic adjunct in other defects of intestinal vitamin B12 absorption. Launch Date 1970

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

The suggested oral dose range for the average patient (70 kg)when performing a Schilling urinary excretion test is between 18.5 to 37 kBq (0.5 to 1 microcurie) of cyanocobalamin Co 57. The patient dose in each Cyanocobalamin Co 57 Capsule should be measured by a suitable radioacttivity calibration system immediately prior to administration.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:10:09 GMT 2025` Edited by `admin` on `Mon Mar 31 18:10:09 GMT 2025`
Record UNII	ZL40NE83QQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COBALTOUS CHLORIDE CO-57

Common Name

English

COBALTOUS CHLORIDE CO 57

Preferred Name

English

COBALTOUS CHLORIDE CO 57 [USAN]

Common Name

English

COBALT CHLORIDE CO-57 [ORANGE BOOK]

Common Name

English

COBALT CHLORIDE, CO-57

Common Name

English

COBALT CHLORIDE CO-57

Common Name

English

RUBRATOPE-57 KIT COMPONENT COBALT CHLORIDE CO-57

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1446