Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H15ClN2OS |
| Molecular Weight | 318.821 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=CC2=C(S1)N(C)C(=O)CN=C2C3=C(Cl)C=CC=C3
InChI
InChIKey=CHBRHODLKOZEPZ-UHFFFAOYSA-N
InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3
| Molecular Formula | C16H15ClN2OS |
| Molecular Weight | 318.821 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Clotiazepam is a compound of the benzodiazepine class. The drug was developed in Japan and approved for the treatment of insomnia, anxiety and before anesthesia. Clotiazepam was marketed worlwide under different names, however, currently it is available only in South America under the name Neuroval and presumably in Japan. Clotiazepam exerts its action by binding and activating GABA-A receptors.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2109243 |
184.0 nM [EC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | DISTENSAN Approved UseDoctors prescribe Distensan for disorders in the sleep rhythm and all forms of insomnia, especially when there are difficulties in falling asleep, either initially or after premature awakening. In most cases only a short-term treatment with Distensan (usually not more than two weeks) is needed. Distensan is also used for the treatment of anxiety, nervous tension, irritability emotional disturbances and before anesthesia (anesthetic premedication). |
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| Primary | NEUROVAL Approved UseThe treatment of anxiety. |
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| Preventing | DISTENSAN Approved UseDoctors prescribe Distensan for disorders in the sleep rhythm and all forms of insomnia, especially when there are difficulties in falling asleep, either initially or after premature awakening. In most cases only a short-term treatment with Distensan (usually not more than two weeks) is needed. Distensan is also used for the treatment of anxiety, nervous tension, irritability emotional disturbances and before anesthesia (anesthetic premedication). |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives. | 1975 Oct 31 |
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| Clotiazepam-induced acute hepatitis. | 1989 Sep |
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| [Who is the underdog? The case of tea producers in Rize]. | 2001 |
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| Thyroid consequences of the Chernobyl nuclear power station accident on the Turkish population. | 2003 May |
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| Anoxybacillus ayderensis sp. nov. and Anoxybacillus kestanbolensis sp. nov. | 2004 Sep |
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| Fixed food eruption caused by lactose identified after oral administration of four unrelated drugs. | 2005 Feb |
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| Isolation, identification and seasonal distribution of soilborne fungi in tea growing areas of Iyidere-Ikizdere vicinity (Rize-Turkey). | 2006 |
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| [The prevalence of cigarette smoking in the Eastern Black Sea Region]. | 2007 |
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| The past and present day of kiwifruit (Actinidia deliciosa Planch.) breeding in Pazar watershed, Turkey. | 2007 Apr 15 |
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| Imported Crimean-Congo hemorrhagic fever cases in Istanbul. | 2007 Jun 6 |
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| Radioactive contamination in lichens collected from Trabzon and Rize in the Eastern Black Sea Region, Turkey, and a comparison with that of 1995. | 2008 May |
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| Benzodiazepine metabolism: an analytical perspective. | 2008 Oct |
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| Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. | 2008 Oct |
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| Phobic postural vertigo treated with autogenic training: a case report. | 2008 Sep 30 |
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| Geo-relationship between cancer cases and the environment by GIS: a case study of Trabzon in Turkey. | 2009 Dec |
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| Inclusion of thienodiazepines in prescription rate of anxiolytics. | 2009 Jun |
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| Effects of land-use changes on landslides in a landslide-prone area (Ardesen, Rize, NE Turkey). | 2009 Sep |
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| The first record of Gregarina typographi Fuchs (Protista: Apicomplexa: Gregarinidae) from the European spruce bark beetle, Ips typographus (Linnaeus) (Coleoptera: Curculionidae, Scolytinae) in Turkey. | 2010 |
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| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
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| Molecular evidence for Anaplasma phagocytophilum in Ixodes ricinus from Turkey. | 2010 Jan |
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| A new species of Tegenaria Latreille, 1804 (Araneae, Agelenidae) from Turkey. | 2010 Jul 23 |
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| The prevalence of nutritional anemia in pregnancy in an east Anatolian province, Turkey. | 2010 Jun 10 |
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| Assessment of the impact of altitude on nasal airflow via expiratory nasal sound spectral analysis. | 2010 Nov |
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| Assessing the autoantibody levels in relation to disease severity and therapy response in pemphigus patients. | 2010 Oct |
Patents
Sample Use Guides
Treatment of anxiety: the usual dose in adults is 1 tablet (10 mg) 1 to 3 times a day for 8-12 weeks. Treatment of insomnia: the usual adult dose is 1 tablet (10 mg) to 2 tablets (20 mg) administered at night, before bedtime. The duration of treatment is usually 2-4 weeks.
Route of Administration:
Oral
| Substance Class |
Chemical
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ZCN055599V
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Validated (UNII)
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NCI_THESAURUS |
C1012
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DEA NO. |
2752
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WHO-VATC |
QN05BA21
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N05BA21
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SUB06773MIG
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100000092585
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C084599
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251-627-3
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C80672
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DB01559
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2622
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33671-46-4
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CLOTIAZEPAM
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m3670
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CHEMBL1697737
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DTXSID0022852
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ACTIVE MOIETY |
