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Details

Stereochemistry ACHIRAL
Molecular Formula C16H15ClN2OS
Molecular Weight 318.821
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOTIAZEPAM

SMILES

CCC1=CC2=C(S1)N(C)C(=O)CN=C2C3=C(Cl)C=CC=C3

InChI

InChIKey=CHBRHODLKOZEPZ-UHFFFAOYSA-N
InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C16H15ClN2OS
Molecular Weight 318.821
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Clotiazepam is a compound of the benzodiazepine class. The drug was developed in Japan and approved for the treatment of insomnia, anxiety and before anesthesia. Clotiazepam was marketed worlwide under different names, however, currently it is available only in South America under the name Neuroval and presumably in Japan. Clotiazepam exerts its action by binding and activating GABA-A receptors.

CNS Activity

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
 184.0 nM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
DISTENSAN

Approved Use

Doctors prescribe Distensan for disorders in the sleep rhythm and all forms of insomnia, especially when there are difficulties in falling asleep, either initially or after premature awakening. In most cases only a short-term treatment with Distensan (usually not more than two weeks) is needed. Distensan is also used for the treatment of anxiety, nervous tension, irritability emotional disturbances and before anesthesia (anesthetic premedication).
Primary
Approved
8429
NEUROVAL

Approved Use

The treatment of anxiety.
Preventing
Approved
8429
DISTENSAN

Approved Use

Doctors prescribe Distensan for disorders in the sleep rhythm and all forms of insomnia, especially when there are difficulties in falling asleep, either initially or after premature awakening. In most cases only a short-term treatment with Distensan (usually not more than two weeks) is needed. Distensan is also used for the treatment of anxiety, nervous tension, irritability emotional disturbances and before anesthesia (anesthetic premedication).
PubMed

PubMed

TitleDatePubMed
Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives.
1975 Oct 31
Clotiazepam-induced acute hepatitis.
1989 Sep
Bilateral angle closure glaucoma and visual loss precipitated by antidepressant and antianxiety agents in a patient with depression.
2000 Sep-Oct
[Who is the underdog? The case of tea producers in Rize].
2001
Anoxybacillus ayderensis sp. nov. and Anoxybacillus kestanbolensis sp. nov.
2004 Sep
Fixed food eruption caused by lactose identified after oral administration of four unrelated drugs.
2005 Feb
Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs.
2005 Sep
Isolation, identification and seasonal distribution of soilborne fungi in tea growing areas of Iyidere-Ikizdere vicinity (Rize-Turkey).
2006
Quantification of clotiazepam in human plasma by gas chromatography-mass spectrometry.
2006 Apr 13
Localization of telomeres and telomere-associated proteins in telomerase-negative Saccharomyces cerevisiae.
2007
[Screening of intestinal parasites of children in special day nurseries in the city of Rize].
2007
Imported Crimean-Congo hemorrhagic fever cases in Istanbul.
2007 Jun 6
Determination of radioactivity levels and hazards of soil and sediment samples in Firtina Valley (Rize, Turkey).
2007 Nov
Echocardiographic predictors of severe heart failure symptoms in hypertrophic cardiomyopathy patients with sinus rhythm.
2008 Feb 29
Radioactive contamination in lichens collected from Trabzon and Rize in the Eastern Black Sea Region, Turkey, and a comparison with that of 1995.
2008 May
Benzodiazepine metabolism: an analytical perspective.
2008 Oct
Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits.
2008 Oct
Geo-relationship between cancer cases and the environment by GIS: a case study of Trabzon in Turkey.
2009 Dec
Spatiotemporal changes of landscape pattern in response to deforestation in Northeastern Turkey: a case study in Rize.
2009 Jan
Effects of land-use changes on landslides in a landslide-prone area (Ardesen, Rize, NE Turkey).
2009 Sep
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Molecular evidence for Anaplasma phagocytophilum in Ixodes ricinus from Turkey.
2010 Jan
A new species of Tegenaria Latreille, 1804 (Araneae, Agelenidae) from Turkey.
2010 Jul 23
Assessment of the impact of altitude on nasal airflow via expiratory nasal sound spectral analysis.
2010 Nov
Assessing the autoantibody levels in relation to disease severity and therapy response in pemphigus patients.
2010 Oct
Patents

Patents

JP2002509462A
1

Sample Use Guides

In Vivo Use Guide
Treatment of anxiety: the usual dose in adults is 1 tablet (10 mg) 1 to 3 times a day for 8-12 weeks. Treatment of insomnia: the usual adult dose is 1 tablet (10 mg) to 2 tablets (20 mg) administered at night, before bedtime. The duration of treatment is usually 2-4 weeks.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 15:54:45 UTC 2023
Edited
by admin
on Sat Dec 16 15:54:45 UTC 2023
Record UNII
ZCN055599V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CLOTIAZEPAM
INN   MART.   MI   WHO-DD  
INN  
Official Name English
CLOTIAZEPAM [MI]
Common Name English
CLOTIAZEPAM [MART.]
Common Name English
Clotiazepam [WHO-DD]
Common Name English
RIZE
Brand Name English
5-(O-CHLOROPHENYL)-7-ETHYL-1,3-DIHYDRO-1-METHYL-2H-THIENO(2,3-E)-1,4-DIAZEPIN-2-ONE
Common Name English
CLOTIAZEPAM [JAN]
Common Name English
clotiazepam [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1012
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
DEA NO. 2752
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
WHO-VATC QN05BA21
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
WHO-ATC N05BA21
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
Code System Code Type Description
EVMPD
SUB06773MIG
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
SMS_ID
100000092585
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
MESH
C084599
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
PUBCHEM
2811
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
ECHA (EC/EINECS)
251-627-3
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
NCI_THESAURUS
C80672
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
DRUG BANK
DB01559
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
FDA UNII
ZCN055599V
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
RXCUI
2622
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY RxNorm
CAS
33671-46-4
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
WIKIPEDIA
CLOTIAZEPAM
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
INN
3496
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
MERCK INDEX
m3670
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1697737
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
EPA CompTox
DTXSID0022852
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
DRUG CENTRAL
718
Created by admin on Sat Dec 16 15:54:45 UTC 2023 , Edited by admin on Sat Dec 16 15:54:45 UTC 2023
PRIMARY
Related Record Type Details
Structure of CLOTIAZEPAM
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