RAMNODIGIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H44O6
Molecular Weight	488.6561
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]1(CC[C@@H](O)[C@H](C)O1)O[C@H]2CC[C@@]3(C)[C@]([H])(CC[C@]4([H])[C@]3([H])CC[C@]5(C)[C@H](CC[C@]45O)C6=CC(=O)OC6)C2

InChI

InChIKey=LDZRENBZALBYIS-XZUAUHNRSA-N

InChI=1S/C29H44O6/c1-17-24(30)6-7-26(34-17)35-20-8-11-27(2)19(15-20)4-5-23-22(27)9-12-28(3)21(10-13-29(23,28)32)18-14-25(31)33-16-18/h14,17,19-24,26,30,32H,4-13,15-16H2,1-3H3/t17-,19+,20-,21+,22-,23+,24+,26-,27-,28+,29-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C29H44O6
Molecular Weight	488.6561
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21572583 | https://pubs.acs.org/doi/full/10.1021/ml100290d?source=chemport | https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=&CC=DE&NR=901C&KC=C

Ramnodigin is a cardenolide derivative patented by Farbwerke Hoechst A.-G. as cardiotonic, diuretic, and antidiarrheic compound. In in vitro studies, Ramnodigin shows cytotoxicity against nonsmall cell human lung cancer cells.

Originator

Approval Year

PubMed

Title	Date	PubMed
C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.	2011 Apr 14	21572583

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:35:21 GMT 2023` Edited by `admin` on `Fri Dec 15 16:35:21 GMT 2023`
Record UNII	Z8SRY7BR30
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RAMNODIGIN

Official Name

English

ramnodigin [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78322