Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C38H53N3O3 |
| Molecular Weight | 599.8457 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C[C@H](N(C)CC1=CC=C(C=C1)C(C)(C)C)C(=O)N[C@@H](CC2=CC=C(OCC3=CC=CC=C3)C=C2)C(=O)NC(C)(C)C
InChI
InChIKey=GCDHMGROXQUFNR-HEVIKAOCSA-N
InChI=1S/C38H53N3O3/c1-27(2)23-34(41(9)25-29-15-19-31(20-16-29)37(3,4)5)36(43)39-33(35(42)40-38(6,7)8)24-28-17-21-32(22-18-28)44-26-30-13-11-10-12-14-30/h10-22,27,33-34H,23-26H2,1-9H3,(H,39,43)(H,40,42)/t33-,34-/m0/s1
| Molecular Formula | C38H53N3O3 |
| Molecular Weight | 599.8457 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
PD 173212 is a potent, selective N-type voltage-gated Ca2+ channel blocker (IC50 = 36 nM), it possesses selectivity for non L-type
Ca ÷2 channels versus neuronal Na ÷, K ÷, and L-type Ca ÷2 channels. PD 173212 demonstrated potent in vitro activity in the IMR-32 assay as well as in
electrophysiology, and it was efficacious in the audiogenic seizure mouse model.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10406647 | https://www.ncbi.nlm.nih.gov/pubmed/10465535
Curator's Comment: # Pfizer (Parke-Davis Pharmaceutical)
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:29:54 GMT 2023
by
admin
on
Sat Dec 16 09:29:54 GMT 2023
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| Record UNII |
Z7UUP5FPKC
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| Record Status |
Validated (UNII)
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| Record Version |
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Z7UUP5FPKC
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DTXSID10432752
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9916734
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admin on Sat Dec 16 09:29:55 GMT 2023 , Edited by admin on Sat Dec 16 09:29:55 GMT 2023
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