U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C8H12N2
Molecular Weight 136.1943
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEBANAZINE

SMILES

CC(NN)C1=CC=CC=C1

InChI

InChIKey=HHRZAEJMHSGZNP-UHFFFAOYSA-N
InChI=1S/C8H12N2/c1-7(10-9)8-5-3-2-4-6-8/h2-7,10H,9H2,1H3

HIDE SMILES / InChI

Molecular Formula C8H12N2
Molecular Weight 136.1943
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Mebanazine is an inhibitor of monoamine oxidase. It was introduced in the 1960s for the treatment of depression and was marketed under trade name Actomol. The drug was withdrawn from the market due to hepatotoxicity. In addition to its antidepressant effect, the drug was found to possess an anorexic action and in animal models, it potentiated the hypoglycemic response to insulin and delayed the recovery of blood glucose levels to normal.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Clinical trial of mebanazine--a new monoamine oxidase inhibitor.
1965 Sep
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:52:27 GMT 2023
Edited
by admin
on Sat Dec 16 17:52:27 GMT 2023
Record UNII
Z5R55CJ4CG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEBANAZINE
INN   MART.   WHO-DD  
INN  
Official Name English
Mebanazine [WHO-DD]
Common Name English
HYDRAZINE, (1-PHENYLETHYL)-
Systematic Name English
(1-PHENYLETHYL)HYDRAZINE
Systematic Name English
mebanazine [INN]
Common Name English
ACTAMOL
Brand Name English
.ALPHA.-METHYLBENZYLHYDRAZINE
Systematic Name English
MEBANAZINE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C667
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL1909283
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
INN
1722
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-615-6
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
SMS_ID
100000081729
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
NCI_THESAURUS
C80969
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
EVMPD
SUB08659MIG
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
MESH
C004343
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
DRUG BANK
DB09248
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
PUBCHEM
6179
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
FDA UNII
Z5R55CJ4CG
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
CAS
65-64-5
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
DRUG CENTRAL
4865
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
WIKIPEDIA
Mebanazine
Created by admin on Sat Dec 16 17:52:27 GMT 2023 , Edited by admin on Sat Dec 16 17:52:27 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY