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Details

Stereochemistry ACHIRAL
Molecular Formula C15H17N5S.C4H4O4
Molecular Weight 415.466
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of PENTIAPINE MALEATE

SMILES

OC(=O)\C=C/C(O)=O.CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=NC=CN24

InChI

InChIKey=VVNCUDFIJWCVHI-BTJKTKAUSA-N
InChI=1S/C15H17N5S.C4H4O4/c1-18-8-10-19(11-9-18)14-17-12-4-2-3-5-13(12)21-15-16-6-7-20(14)15;5-3(6)1-2-4(7)8/h2-7H,8-11H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula C15H17N5S
Molecular Weight 299.394
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Pentiapine is a dopamine release inhibitor. It is a tranquiliser. Pentiapine produces a dose-dependent decrease in spontaneous motor activity and blocks the morphineinduced hyperactivity. Moreover, this drug in itself has no effect on place conditioning but blocks the acquisition of morphine-induced conditioned place preference.

Approval Year

PubMed

PubMed

TitleDatePubMed
CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences.
1998 Jan
Effects of CGS 10746B on hyperactivity and place preference induced by morphine.
2001 Nov 29
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Mice data
24 and 32 mg/kg
Route of Administration: Intraperitoneal
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:09:05 GMT 2025
Edited
by admin
on Mon Mar 31 18:09:05 GMT 2025
Record UNII
Z5P36MQ43L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CGS 10746B
Preferred Name English
PENTIAPINE MALEATE
USAN  
USAN  
Official Name English
5-(4-Methyl-1-piperazinyl)imidazo[2,1-b][1,3,5]benzothiadiazepine maleate (1:1)
Systematic Name English
IMIDAZO(2,1-B)(1,3,5)BENZOTHIADIAZEPINE, 5-(4-METHYL-1-PIPERAZINYL)-, (Z)-2-BUTENEDIOATE(1:1)
Systematic Name English
CGS-10746B
Code English
PENTIAPINE MALEATE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
Code System Code Type Description
FDA UNII
Z5P36MQ43L
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
PRIMARY
PUBCHEM
6435401
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
PRIMARY
NCI_THESAURUS
C90844
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
PRIMARY
USAN
X-31
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
PRIMARY
SMS_ID
300000055583
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
PRIMARY
CAS
81382-52-7
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
PRIMARY
ChEMBL
CHEMBL2105337
Created by admin on Mon Mar 31 18:09:05 GMT 2025 , Edited by admin on Mon Mar 31 18:09:05 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY