PENTIAPINE MALEATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17N5S.C4H4O4
Molecular Weight	415.466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CN1CCN(CC1)C2=NC3=C(SC4=NC=CN24)C=CC=C3

InChI

InChIKey=VVNCUDFIJWCVHI-BTJKTKAUSA-N

InChI=1S/C15H17N5S.C4H4O4/c1-18-8-10-19(11-9-18)14-17-12-4-2-3-5-13(12)21-15-16-6-7-20(14)15;5-3(6)1-2-4(7)8/h2-7H,8-11H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula	C15H17N5S
Molecular Weight	299.394
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11704248 | https://www.ncbi.nlm.nih.gov/pubmed/9443558 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 948, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Pentiapine is a dopamine release inhibitor. It is a tranquiliser. Pentiapine produces a dose-dependent decrease in spontaneous motor activity and blocks the morphineinduced hyperactivity. Moreover, this drug in itself has no effect on place conditioning but blocks the acquisition of morphine-induced conditioned place preference.

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

24 and 32 mg/kg

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:48:01 GMT 2023` Edited by `admin` on `Fri Dec 15 15:48:01 GMT 2023`
Record UNII	Z5P36MQ43L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PENTIAPINE MALEATE

Official Name

English

CGS 10746B

Code

English

5-(4-Methyl-1-piperazinyl)imidazo[2,1-b][1,3,5]benzothiadiazepine maleate (1:1)

Systematic Name

English

IMIDAZO(2,1-B)(1,3,5)BENZOTHIADIAZEPINE, 5-(4-METHYL-1-PIPERAZINYL)-, (Z)-2-BUTENEDIOATE(1:1)

Systematic Name

English

CGS-10746B

Code

English

PENTIAPINE MALEATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710