PENTIAPINE MALEATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17N5S.C4H4O4
Molecular Weight	415.466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=NC=CN24

InChI

InChIKey=VVNCUDFIJWCVHI-BTJKTKAUSA-N

InChI=1S/C15H17N5S.C4H4O4/c1-18-8-10-19(11-9-18)14-17-12-4-2-3-5-13(12)21-15-16-6-7-20(14)15;5-3(6)1-2-4(7)8/h2-7H,8-11H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula	C15H17N5S
Molecular Weight	299.394
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11704248 | https://www.ncbi.nlm.nih.gov/pubmed/9443558 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 948, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Pentiapine is a dopamine release inhibitor. It is a tranquiliser. Pentiapine produces a dose-dependent decrease in spontaneous motor activity and blocks the morphineinduced hyperactivity. Moreover, this drug in itself has no effect on place conditioning but blocks the acquisition of morphine-induced conditioned place preference.

Approval Year

PubMed

Title	Date	PubMed
CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences.	1998 Jan	9443558
Effects of CGS 10746B on hyperactivity and place preference induced by morphine.	2001 Nov 29	11704248

Patents

Sample Use Guides

In Vivo Use Guide

24 and 32 mg/kg

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:09:05 GMT 2025` Edited by `admin` on `Mon Mar 31 18:09:05 GMT 2025`
Record UNII	Z5P36MQ43L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CGS 10746B

Preferred Name

English

PENTIAPINE MALEATE

Official Name

English

5-(4-Methyl-1-piperazinyl)imidazo[2,1-b][1,3,5]benzothiadiazepine maleate (1:1)

Systematic Name

English

IMIDAZO(2,1-B)(1,3,5)BENZOTHIADIAZEPINE, 5-(4-METHYL-1-PIPERAZINYL)-, (Z)-2-BUTENEDIOATE(1:1)

Systematic Name

English

CGS-10746B

Code

English

PENTIAPINE MALEATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710