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Details

Stereochemistry ACHIRAL
Molecular Formula C15H17N5S
Molecular Weight 299.394
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PENTIAPINE

SMILES

CN1CCN(CC1)C2=NC3=C(SC4=NC=CN24)C=CC=C3

InChI

InChIKey=FACMWMBWGSPRKO-UHFFFAOYSA-N
InChI=1S/C15H17N5S/c1-18-8-10-19(11-9-18)14-17-12-4-2-3-5-13(12)21-15-16-6-7-20(14)15/h2-7H,8-11H2,1H3

HIDE SMILES / InChI

Molecular Formula C15H17N5S
Molecular Weight 299.394
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pentiapine is a dopamine release inhibitor. It is a tranquiliser. Pentiapine produces a dose-dependent decrease in spontaneous motor activity and blocks the morphineinduced hyperactivity. Moreover, this drug in itself has no effect on place conditioning but blocks the acquisition of morphine-induced conditioned place preference.

Approval Year

PubMed

PubMed

TitleDatePubMed
CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences.
1998 Jan
Effects of CGS 10746B on hyperactivity and place preference induced by morphine.
2001 Nov 29
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Mice data
24 and 32 mg/kg
Route of Administration: Intraperitoneal
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:36:52 UTC 2023
Edited
by admin
on Fri Dec 15 16:36:52 UTC 2023
Record UNII
RAP39VD6P5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PENTIAPINE
INN  
INN  
Official Name English
5-(4-METHYL-1-PIPERAZINYL)IMIDAZO(2,1-B)(1,3,5)BENZOTHIADIAZEPINE
Systematic Name English
pentiapine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66883
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
NCI_THESAURUS C29710
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
Code System Code Type Description
PUBCHEM
54742
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
SMS_ID
100000082533
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
CAS
81382-51-6
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
ChEMBL
CHEMBL2105337
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
INN
6044
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
EVMPD
SUB09693MIG
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
NCI_THESAURUS
C132843
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
EPA CompTox
DTXSID60231075
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
FDA UNII
RAP39VD6P5
Created by admin on Fri Dec 15 16:36:52 UTC 2023 , Edited by admin on Fri Dec 15 16:36:52 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY