Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H11NO.ClH |
| Molecular Weight | 173.64 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NCCC1=CC=C(O)C=C1
InChI
InChIKey=RNISDHSYKZAWOK-UHFFFAOYSA-N
InChI=1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C8H11NO |
| Molecular Weight | 137.179 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Tyramine is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine occurs widely in plants and animals, and is metabolized by the enzyme monoamine oxidase. Tyramine is an alpha-adrenergic agonist. Hypertension can occur, from ingestion of tyramine-rich foods in conjunction with monoamine oxidase inhibitors. The possibility that tyramine acts directly as a neurotransmitter was revealed by the discovery of a G protein-coupled receptor with high affinity for tyramine, called TAAR. It exhibits sympathomimetic effects by causing the release of endogenic norepinephrine. It has been used in mydriatic eyedrops. This has been said to reduce the intraocular pressure in rabbits and in some patients with open-angle glaucoma.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL5857 |
0.2 µM [EC50] | ||
Target ID: Q9P1P5 Gene ID: 9287.0 Gene Symbol: TAAR2 Target Organism: Homo sapiens (Human) |
0.52 nM [EC50] | ||
Target ID: P31513 Gene ID: 2328.0 Gene Symbol: FMO3 Target Organism: Homo sapiens (Human) |
|||
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat. | 1999 Dec |
|
| Modulation of gastrin processing by vesicular monoamine transporter type 1 (VMAT1) in rat gastrin cells. | 1999 Jun 1 |
|
| Why do some dietary migraine patients claim they get headaches from placebos? | 2000 May |
|
| Quantification of tumour vascularity in squamous cell carcinoma of the tongue using CARD amplification, a systematic sampling technique, and true colour image analysis. | 2001 |
|
| Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation. | 2001 Apr |
|
| Effect of the interaction between a low tyramine-producing Lactobacillus and proteolytic staphylococci on biogenic amine production during ripening and storage of dry sausages. | 2001 Apr 11 |
|
| Functional expression of a locust tyramine receptor in murine erythroleukaemia cells. | 2001 Dec |
|
| DNA recombination and RNA cleavage activities of the Flp protein: roles of two histidine residues in the orientation and activation of the nucleophile for strand cleavage. | 2001 Dec 7 |
|
| Octopamine influences division of labor in honey bee colonies. | 2001 Feb |
|
| Immunocytochemical localization of acyl-CoA oxidase in the rat central nervous system. | 2001 Jan |
|
| Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase. | 2001 Jan |
|
| Formation of biogenic amines in bulk-stored chilled hake (Merluccius merluccius L.) packed under atmospheres. | 2001 Jul |
|
| [The content of biogenic amines in canned fish from the Turkish market]. | 2001 Jul-Aug |
|
| Evolution of microbial populations and biogenic amine production in dry sausages produced in Southern Italy. | 2001 Jun |
|
| Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs. | 2001 Jun |
|
| Amino acid-decarboxylase activity of bacteria isolated from fermented pork sausages. | 2001 Jun 15 |
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| Amine oxidase substrates mimic several of the insulin effects on adipocyte differentiation in 3T3 F442A cells. | 2001 Jun 15 |
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| Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. | 2001 Mar |
|
| The role of alpha(1)-adrenoceptors and 5-HT(1A) receptors in the control of the micturition reflex in male anaesthetized rats. | 2001 May |
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| Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects. | 2001 May |
|
| [New development of hair examination! The searching of hair for the terminal residual substance of pleasant sensation]. | 2001 Nov |
|
| Apical dominance in Pssu-ipt-transformed tobacco. | 2001 Nov |
|
| Applications of enzymatic amplification staining in immunophenotyping hematopoietic cells. | 2002 Apr 1 |
|
| Iron (III) attenuates hydroxyl radical generation accompanying non-enzymatic oxidation of noradrenaline in the rat heart. | 2002 Feb |
|
| Linezolid: its role in the treatment of gram-positive, drug-resistant bacterial infections. | 2002 Feb 15 |
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| Enzymatic decarboxylation of tyrosine and phenylalanine to enhance volatility for high-precision isotopic analysis. | 2002 Jan 15 |
|
| On-line synthesis utilizing immobilized enzyme reactors based upon immobilized dopamine beta-hydroxylase. | 2002 Jan 5 |
|
| A high-affinity octopamine transporter cloned from the central nervous system of cabbage looper Trichoplusia ni. | 2002 Mar 1 |
Sample Use Guides
1.25 ug, 4.75 ug, 12.5 ug, 47.5 ug, 125 ug, and 475 ug twice weekly with a minimum of 48 h between doses. The six doses were given in ascending order.
Route of Administration:
Topical
In rat cardiomyocytes, 0.3 mM tyramine activated 2-deoxyglucose uptake to around 40% of the maximal insulin effect and benzylamine had no effect. Concentration-dependent studies showed that the EC50 of tyramine in activating hexose uptake was 10 uM in cardiomyocytes, whereas in the presence of vanadate, the EC50 of tyramine was 117 uM in adipocytes.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:03:36 GMT 2023
by
admin
on
Fri Dec 15 15:03:36 GMT 2023
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| Record UNII |
Z5KDH3H147
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| Record Status |
Validated (UNII)
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| Record Version |
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m11286
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200-462-5
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DBSALT002213
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236897
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66449
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Z5KDH3H147
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100000077292
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SUB15651MIG
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