Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H17F3N2O2 |
| Molecular Weight | 350.335 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(\C=N\N(C(=O)C(F)(F)F)C2=CC=C(C)C=C2C)=CC=C1
InChI
InChIKey=HYMZAYGFKNNHDN-SSDVNMTOSA-N
InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
| Molecular Formula | C18H17F3N2O2 |
| Molecular Weight | 350.335 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Deciphering the 'Elixir of Life': Dynamic Perspectives into the Allosteric Modulation of Mitochondrial ATP Synthase by J147, a Novel Drug in the Treatment of Alzheimer's Disease. | 2019-06 |
|
| The mitochondrial ATP synthase is a shared drug target for aging and dementia. | 2018-04 |
|
| A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. | 2011 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:53:01 GMT 2025
by
admin
on
Mon Mar 31 20:53:01 GMT 2025
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| Record UNII |
Z41H3C5BT9
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
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Preferred Name | English | ||
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Code | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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1807913-16-1
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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PRIMARY | |||
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1146963-51-0
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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NON-SPECIFIC STEREOCHEMISTRY | |||
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DTXSID501045787
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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DB13957
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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25229652
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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J147
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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PRIMARY | J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. The approach that lead to development of the J147 drug was to screen candidate molecules for anti-aging effects, instead of targeting the amyloid plaques. It is contrary to the most of other approaches to develop drugs against the Alzheimer's disease that target the plaque deposits in the brain. The J147 drug is also reported to address other biological aging factors, such as preventing the leakage of blood from microvessels in mice brains. | ||
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J147
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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PRIMARY | |||
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J147
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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PRIMARY | Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble A.BETA.40 and A.BETA.42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active. | ||
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Z41H3C5BT9
Created by
admin on Mon Mar 31 20:53:01 GMT 2025 , Edited by admin on Mon Mar 31 20:53:01 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
