Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H6N2O2 |
| Molecular Weight | 138.124 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ONC(=O)C1=CC=CN=C1
InChI
InChIKey=IYCHDNQCHLMLJZ-UHFFFAOYSA-N
InChI=1S/C6H6N2O2/c9-6(8-10)5-2-1-3-7-4-5/h1-4,10H,(H,8,9)
| Molecular Formula | C6H6N2O2 |
| Molecular Weight | 138.124 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Nicoxamat (nicotinohydroxamic acid) is a uricosuric drug that increased urinary excretion of urea and depressed urease activity in the stomach and the colon. Patients receiving nicoxamat showed significant improvement in blood ammonia levels as compared to patients receiving neomycin. In a double-blind clinical trial, 24 patients with the advanced chronic liver disease received 1.2 g of the drug daily. Nicoxamat induced some side effects, such as mild diarrhea, constipation, and anorexia.
Approval Year
Sample Use Guides
In a double-blind clinical trial 24 patients with advanced chronic liver disease
received 1.2 g of Nicoxamat (nicotinohydroxamic acid) daily. The drugs used in this study were uncoated white
tablets each of which contained 200 mg of nicotinohydroxamic acid.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:41:57 GMT 2023
by
admin
on
Fri Dec 15 15:41:57 GMT 2023
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| Record UNII |
Z3H2D4MF7A
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C921
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4934
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CHEMBL504369
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DTXSID70205126
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Z3H2D4MF7A
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SUB09249MIG
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C020427
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C77068
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13997
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100000084419
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5657-61-4
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71211
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
