CETAMOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H26N2O4
Molecular Weight	310.3886
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=O)COC1=C(OCC(O)CNC(C)(C)C)C=CC=C1

InChI

InChIKey=UWCBNAVPISMFJZ-UHFFFAOYSA-N

InChI=1S/C16H26N2O4/c1-16(2,3)18-9-12(19)10-21-13-7-5-6-8-14(13)22-11-15(20)17-4/h5-8,12,18-19H,9-11H2,1-4H3,(H,17,20)

HIDE SMILES / InChI

Molecular Formula	C16H26N2O4
Molecular Weight	310.3886
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2905711 | https://www.ncbi.nlm.nih.gov/pubmed/2901435 | https://www.ncbi.nlm.nih.gov/pubmed/2899095

Cetamolol is a beta adrenergic antagonist with intrinsic sympathomimetic activity, patented by Imperial Chemical Industries Ltd for cardiovascular disease treatment. The average plasma half-life of cetamolol is 6.4 hours in humans and peak serum levels are reached 1 to 2 hours after drug intake; oral doses as low as 10 mg produced significant reductions in exercise-induced tachycardia 24 hours after drug administration. Cetamolol is approximately three times as potent as atenolol in blocking exercise-induced tachycardia.

Originator

Approval Year

PubMed

Title	Date	PubMed
Cetamolol: a new cardioselective beta-adrenoceptor blocking agent without membrane-stabilizing activity.	1984 Mar	6144380
Effect of cetamolol on epinephrine-induced hypokalemia.	1988 Aug	2905711
Comparison of the effects of cetamolol and atenolol on epinephrine- and isoproterenol-induced hypokalemia in anesthetized dogs.	1989 Jan	2468922

Patents

Sample Use Guides

In Vivo Use Guide

15 mg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:31:42 GMT 2023` Edited by `admin` on `Sat Dec 16 16:31:42 GMT 2023`
Record UNII	Z0VD1633O8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CETAMOLOL

Official Name

English

cetamolol [INN]

Common Name

English

ACETAMIDE, 2-(2-(3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPOXY)PHENOXY)-N-METHYL-, (±)-

Systematic Name

English

CETAMOLOL [MI]

Common Name

English

(±)-2-(O-(3-(TERT-BUTYLAMINO)-2-HYDROXYPROPOXY)PHENOXY)-N-METHYLACETAMIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576