CLOTHIAPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18ClN3S
Molecular Weight	343.874
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C2=NC3=C(SC4=C2C=C(Cl)C=C4)C=CC=C3

InChI

InChIKey=KAAZGXDPUNNEFN-UHFFFAOYSA-N

InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H18ClN3S
Molecular Weight	343.874
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://medic.co.il/wp-content/uploads/2013/11/Entumin_dr_minor_changes_1402654028847.pdf
Curator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/9804284

Clothiapine is a neuroleptic of dibenzoepine class that ise used for the treatment of mental disorders. It is supposed that clothiapine acts by blocking GABA (A) receptors. The drug is marketed in some European countries under the name Entumin.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: http://www.ncbi.nlm.nih.gov/pubmed/9804284	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mental and emotional disorders 1 Sources: http://medic.co.il/wp-content/uploads/2013/11/Entumin_dr_minor_changes_1402654028847.pdf	Primary		Approved 8429	ENTUMIN Approved Use For the treatment of severe mental and emotional disorders. Launch Date 2014

PubMed

Title	Date	PubMed
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].	2002 Oct 16	12383353
Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses.	2004	15266432
Clotiapine compared with chlorpromazine in chronic schizophrenia.	2005 Dec 15	16126373
Determination of several psychiatric drugs in whole blood using capillary gas-liquid chromatography with nitrogen phosphorus detection: comparison of two solid phase extraction procedures.	2005 Dec 20	16226158

Sample Use Guides

In Vivo Use Guide

3 to 5 tablets daily (120-200 mg) in 2 or 3 divided doses and then 20 to 160 mg daily per os in 2 to 3 divided doses for maintenance and long-term treatment.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:01:31 GMT 2023` Edited by `admin` on `Fri Dec 15 15:01:31 GMT 2023`
Record UNII	Z05HCY0X1T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOTHIAPINE

Official Name

English

CLOTIAPINE [MART.]

Common Name

English

HF-2159

Code

English

Clotiapine [WHO-DD]

Common Name

English

CLOTIAPINE

Official Name

English

DIBENZO(B,F)(1,4)THIAZEPINE, 2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)-

Systematic Name

English

CLOTHIAPINE [USAN]

Common Name

English

CLOTHIAPINE [MI]

Common Name

English

2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)DIBENZO(B,F)(1,4)THIAZEPINE

Systematic Name

English

CLOTIAPINE [JAN]

Common Name

English

ENTUMIN

Brand Name

English

clotiapine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885