Aclerastide (DSC-127; NorLeu-3-A(1-7)) is an angiotensin analogue that is being developed by Derma Sciences (a subsidiary of Integra LifeSciences) for the treatment for wounds such as diabetic foot ulcer and surgical scars. The mechanisms of action include induction of progenitor proliferation, accelerated vascularization, collagen deposition, and re-epithelialization. Aclerastide recently failed in phase III clinical trials for treatment of diabetic foot ulcers. Phase I development of aclerastide ophthalmic solution is ongoing in the US.
Approval Year
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Protein
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| Sequence Type | COMPLETE |
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YYD6UT8T47
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Validated (UNII)
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FDA ORPHAN DRUG |
414813
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admin on Sat Dec 16 16:41:07 UTC 2023 , Edited by admin on Sat Dec 16 16:41:07 UTC 2023
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FDA ORPHAN DRUG |
414713
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admin on Sat Dec 16 16:41:07 UTC 2023 , Edited by admin on Sat Dec 16 16:41:07 UTC 2023
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9811551
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DB12631
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C169759
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9877
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YYD6UT8T47
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227803-63-6
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admin on Sat Dec 16 16:41:07 UTC 2023 , Edited by admin on Sat Dec 16 16:41:07 UTC 2023
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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