U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Aclerastide (DSC-127; NorLeu-3-A(1-7)) is an angiotensin analogue that is being developed by Derma Sciences (a subsidiary of Integra LifeSciences) for the treatment for wounds such as diabetic foot ulcer and surgical scars. The mechanisms of action include induction of progenitor proliferation, accelerated vascularization, collagen deposition, and re-epithelialization. Aclerastide recently failed in phase III clinical trials for treatment of diabetic foot ulcers. Phase I development of aclerastide ophthalmic solution is ongoing in the US.

Approval Year

PubMed

PubMed

TitleDatePubMed
NorLeu(3)-Angiotensin (1-7) [DSC127] as a Therapy for the Healing of Diabetic Foot Ulcers.
2015 Jun 1
Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers.
2018 Sep 5

Sample Use Guides

Aclerastide 0.03%, daily topical application to diabetic foot ulcer for a period of up to 28 days
Route of Administration: Topical
Substance Class Protein
Created
by admin
on Thu Jul 06 22:08:47 UTC 2023
Edited
by admin
on Thu Jul 06 22:08:47 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
YYD6UT8T47
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ACLERASTIDE
INN   WHO-DD  
INN  
Official Name English
DSC-127
Common Name English
NORLEU3-ANGIOTENSIN(1-7)
Common Name English
Aclerastide [WHO-DD]
Common Name English
DSC127
Code English
USB-001
Code English
NORLEU3-A(1-7)
Common Name English
USB005
Code English
USB-005
Code English
ASP-ARG-NLE-TYR-ILE-HIS-PRO
Common Name English
aclerastide [INN]
Common Name English
1-7-ANGIOTENSIN II, 3-L-NORLEUCINE-5-L-ISOLEUCINE
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 414813
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
FDA ORPHAN DRUG 414713
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
Code System Code Type Description
PUBCHEM
9811551
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
PRIMARY
DRUG BANK
DB12631
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
PRIMARY
NCI_THESAURUS
C169759
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
PRIMARY
INN
9877
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
PRIMARY
FDA UNII
YYD6UT8T47
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
PRIMARY
CAS
227803-63-6
Created by admin on Thu Jul 06 22:08:47 UTC 2023 , Edited by admin on Thu Jul 06 22:08:47 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL