CGS-8216

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H11N3O
Molecular Weight	261.278
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1N(N=C2C1=CNC3=C2C=CC=C3)C4=CC=CC=C4

InChI

InChIKey=WRHJCJHWJSQAHY-UHFFFAOYSA-N

InChI=1S/C16H11N3O/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11/h1-10,17H

HIDE SMILES / InChI

Molecular Formula	C16H11N3O
Molecular Weight	261.278
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
GABA-A receptor; alpha-6/beta-3/gamma-2 6 Target ID: CHEMBL2095190 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2849	17.0 nM [Ki]
GABA-A receptor; alpha-3/beta-3/gamma-2 11 Target ID: CHEMBL2094120 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2849	0.12 nM [Ki]
GABA-A receptor; alpha-1/beta-3/gamma-2 16 Target ID: CHEMBL2094121 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2849	0.05 nM [Ki]
GABA-A receptor; alpha-2/beta-3/gamma-2 12 Target ID: CHEMBL2094130 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2849	0.08 nM [Ki]
GABA-A receptor; alpha-5/beta-3/gamma-2 14 Target ID: CHEMBL2094122 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2849	0.25 nM [Ki]

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:19:48 GMT 2025` Edited by `admin` on `Mon Mar 31 19:19:48 GMT 2025`
Record UNII	YXH2C8E92N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CGS-8216

Code

English

CGS8216

Preferred Name

English

2-Phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one

Systematic Name

English

2-Phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-one

Systematic Name

English

2,5-Dihydro-2-phenyl-3H-pyrazolo[4,3-c]quinolin-3-one

Systematic Name

English

3H-Pyrazolo[4,3-c]quinolin-3-one, 2,5-dihydro-2-phenyl-

Systematic Name

English

Code System Code Type Description

CAS

77779-60-3

Created by admin on Mon Mar 31 19:19:48 GMT 2025 , Edited by admin on Mon Mar 31 19:19:48 GMT 2025

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WIKIPEDIA

CGS-8216

Created by admin on Mon Mar 31 19:19:48 GMT 2025 , Edited by admin on Mon Mar 31 19:19:48 GMT 2025

PRIMARY

FDA UNII

YXH2C8E92N

Created by admin on Mon Mar 31 19:19:48 GMT 2025 , Edited by admin on Mon Mar 31 19:19:48 GMT 2025

PRIMARY

EPA CompTox

DTXSID00998973

Created by admin on Mon Mar 31 19:19:48 GMT 2025 , Edited by admin on Mon Mar 31 19:19:48 GMT 2025

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CGS-8216 hydrochloride

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Amount: