CGS-8216 hydrochloride

Cl.O=C1N(N=C2C1=CNC3=C2C=CC=C3)C4=CC=CC=C4

InChIKey=UUUZHALLLIPECV-UHFFFAOYSA-N

InChI=1S/C16H11N3O.ClH/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11;/h1-10,17H;1H

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
GABA-A receptor; alpha-6/beta-3/gamma-2 6 Target ID: CHEMBL2095190 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2778	17.0 nM [Ki]
GABA-A receptor; alpha-3/beta-3/gamma-2 11 Target ID: CHEMBL2094120 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2778	0.12 nM [Ki]
GABA-A receptor; alpha-1/beta-3/gamma-2 16 Target ID: CHEMBL2094121 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2778	0.05 nM [Ki]
GABA-A receptor; alpha-2/beta-3/gamma-2 12 Target ID: CHEMBL2094130 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2778	0.08 nM [Ki]
GABA-A receptor; alpha-5/beta-3/gamma-2 14 Target ID: CHEMBL2094122 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10633039	Antagonist 2778	0.25 nM [Ki]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 19:22:50 GMT 2023` Edited by `admin` on `Sat Dec 16 19:22:50 GMT 2023`
Record UNII	PCX94X6DMD
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

CGS-8216 hydrochloride

Common Name

English

3H-Pyrazolo[4,3-c]quinolin-3-one, 2,5-dihydro-2-phenyl-, hydrochloride (1:1)

Systematic Name

English

3H-Pyrazolo[4,3-c]quinolin-3-one, 2,5-dihydro-2-phenyl-, monohydrochloride

Systematic Name

English

Code System Code Type Description

CAS

92446-68-9

Created by admin on Sat Dec 16 19:22:51 GMT 2023 , Edited by admin on Sat Dec 16 19:22:51 GMT 2023

PRIMARY

FDA UNII

PCX94X6DMD

Created by admin on Sat Dec 16 19:22:51 GMT 2023 , Edited by admin on Sat Dec 16 19:22:51 GMT 2023

PRIMARY

Related Record Type Details


					YXH2C8E92N

CGS-8216

PARENT -> SALT/SOLVATE

Amount: