ARGLABIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H18O3
Molecular Weight	246.3016
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

[H][C@@]12CC[C@]3(C)O[C@@]34CC=C(C)[C@]4([H])[C@@]1([H])OC(=O)C2=C

InChI

InChIKey=UVJYAKBJSGRTHA-CUZKYEQNSA-N

InChI=1S/C15H18O3/c1-8-4-7-15-11(8)12-10(9(2)13(16)17-12)5-6-14(15,3)18-15/h4,10-12H,2,5-7H2,1,3H3/t10-,11+,12-,14-,15+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C15H18O3
Molecular Weight	246.3016
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Protein farnesyltransferase 13	Inhibitor 8,297		25.0 µM [IC50]

Patents

Patents

Substance Class	Chemical
Record UNII	YS8UOP7QZ1
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

ARGLABIN

Common Name

English

(+)-ARGLABIN

Common Name

English

ARGLABINE

Common Name

English

3H-OXIRENO(8,8A)AZULENO(4,5-B)FURAN-8(4AH)-ONE, 5,6,6A,7,9A,9B-HEXAHYDRO-1,4A-DIMETHYL-7-METHYLENE-, (4AS-(3AS*,4A.ALPHA.,6A.ALPHA.,9A.BETA.,9B.ALPHA.))-

Systematic Name

English

3H-OXIRENO(8,8A)AZULENO(4,5-B)FURAN-8(4AH)-ONE, 5,6,6A,7,9A,9B-HEXAHYDRO-1,4A-DIMETHYL-7-METHYLENE-, (3AR,4AS,6AS,9AS,9BR)-

Systematic Name

English

Showing 1 to 5 of 5 entries

Previous1Next

Show entries

Code System

Code

Type

Description

FDA UNII

YS8UOP7QZ1

PRIMARY

CAS

84692-91-1

PRIMARY

WIKIPEDIA

Arglabin

PRIMARY

CHEBI

73228

PRIMARY

EPA CompTox

DTXSID30233687

PRIMARY

Showing 1 to 5 of 6 entries

Previous1 2Next

Show entries

Related Record

Type

Details


					YS8UOP7QZ1

ARGLABIN

ACTIVE MOIETY

Comments:

It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the adduct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers.


					YS8UOP7QZ1

ARGLABIN

ACTIVE MOIETY

Comments:

Arglabin reduces inflammation, plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a HFD. Consequently, a marked reduction of atherosclerotic lesions was observed. Thus, arglabin may represent a new promising drug to treat inflammation and atherosclerosis.


					YS8UOP7QZ1

ARGLABIN

ACTIVE MOIETY

Comments:

Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora.

Showing 1 to 3 of 3 entries

Previous1Next