FENGABINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H17Cl2NO
Molecular Weight	322.229
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC\N=C(\C1=C(O)C=CC(Cl)=C1)C2=C(Cl)C=CC=C2

InChI

InChIKey=ZGLIFVFRIOKQLE-LVZFUZTISA-N

InChI=1S/C17H17Cl2NO/c1-2-3-10-20-17(13-6-4-5-7-15(13)19)14-11-12(18)8-9-16(14)21/h4-9,11,21H,2-3,10H2,1H3/b20-17+

HIDE SMILES / InChI

Molecular Formula	C17H17Cl2NO
Molecular Weight	322.229
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2668780 | https://www.ncbi.nlm.nih.gov/pubmed/3033203 | https://www.ncbi.nlm.nih.gov/pubmed/2281807

FENGABINE, a benzylidene derivative, is a GABAmimetic compound with clinically proven antidepressant action. It inhibits neither monoamine uptake nor monoamine oxidase. It also lacks any sedative effect.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.	1987 Apr	3033203
Fengabine, a new GABAmimetic agent in the treatment of depressive disorders: an overview of six double-blind studies versus tricyclics.	1989	2668780
Therapeutic effects of fengabine, a new GABAergic agent, in depressed outpatients: a double-blind study versus clomipramine.	1990 Nov	2281807

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:55:18 UTC 2023` Edited by `admin` on `Fri Dec 15 15:55:18 UTC 2023`
Record UNII	YQG0NJI5A7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FENGABINE

Official Name

English

PHENOL, 2-((BUTYLIMINO)(2-CHLOROPHENYL)METHYL)-4-CHLORO-, (Z)-

Common Name

English

fengabine [INN]

Common Name

English

SL-79229-00

Code

English

FENGABINE [USAN]

Common Name

English

SL 79.229-00

Code

English

(Z)-2-(N-Butyl-O-chlorobenzimidoyl)-4-chlorophenol

Common Name

English

SL-79.229

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C265