KW-4490

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H19NO5
Molecular Weight	317.3365
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C2OCCOC2=C(C=C1)[C@]3(CC[C@@H](CC3)C(O)=O)C#N

InChI

InChIKey=SBCKAEJLDHJBNZ-QQVUYCAZSA-N

InChI=1S/C17H19NO5/c1-21-13-3-2-12(14-15(13)23-9-8-22-14)17(10-18)6-4-11(5-7-17)16(19)20/h2-3,11H,4-9H2,1H3,(H,19,20)/t11-,17-

HIDE SMILES / InChI

Molecular Formula	C17H19NO5
Molecular Weight	317.3365
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:15:24 GMT 2025` Edited by `admin` on `Mon Mar 31 23:15:24 GMT 2025`
Record UNII	YQ9CYR6ZJM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KW-4490

Code

English

KF 66490

Preferred Name

English

CYCLOHEXANECARBOXYLIC ACID, 4-CYANO-4-(2,3-DIHYDRO-8-METHOXY-1,4-BENZODIOXIN-5-YL)-, CIS-

Systematic Name

English

KW 4490

Code

English

CIS-4-CYANO-4-(2,3-DIHYDRO-8-METHOXY-1,4-BENZODIOXIN-5-YL)CYCLOHEXANE-1-CARBOXYLIC ACID

Systematic Name

English

4-CYANO-4-(5-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXIN-8-YL)CYCLOHEXANECARBOXYLIC ACID

Systematic Name

English

KF-66490

Common Name

English

Code System Code Type Description

CAS

260561-48-6

Created by admin on Mon Mar 31 23:15:24 GMT 2025 , Edited by admin on Mon Mar 31 23:15:24 GMT 2025

PRIMARY

CAS

444659-42-1

Created by admin on Mon Mar 31 23:15:24 GMT 2025 , Edited by admin on Mon Mar 31 23:15:24 GMT 2025

SUPERSEDED

ChemIDplus: Substance Name: KF 66490, RN: 260561-48-6; Other Registry Numbers: 444659-42-1

FDA UNII

YQ9CYR6ZJM

Created by admin on Mon Mar 31 23:15:24 GMT 2025 , Edited by admin on Mon Mar 31 23:15:24 GMT 2025

PRIMARY

Related Record Type Details


					0I0QNC22HS

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE PDE4B1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					YQ9CYR6ZJM

KW-4490

ACTIVE MOIETY

Comments:

KF66490 is a newly developed PDE4 inhibitor that inhibits PDE4B (IC50 = 220 nM) and the production of tumor necrosis factor (TNF)-α by mouse peritoneal exudated cells stimulated with lipopolysaccharide (IC50 = 855 nM). The present results suggest that KF66490 has excellent potential as an oral medicine for the treatment of atopic dermatitis.

Amount:


					YQ9CYR6ZJM

KW-4490

ACTIVE MOIETY

Comments:

Other Registry Numbers: 444659-42-1, 1051982-38-7

Amount:


					YQ9CYR6ZJM

KW-4490

ACTIVE MOIETY

Comments:

A Practical Synthesis of the PDE4 Inhibitor, KW-4490

Amount: