Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H19NO5 |
| Molecular Weight | 317.3365 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2OCCOC2=C(C=C1)[C@]3(CC[C@@H](CC3)C(O)=O)C#N
InChI
InChIKey=SBCKAEJLDHJBNZ-QQVUYCAZSA-N
InChI=1S/C17H19NO5/c1-21-13-3-2-12(14-15(13)23-9-8-22-14)17(10-18)6-4-11(5-7-17)16(19)20/h2-3,11H,4-9H2,1H3,(H,19,20)/t11-,17-
| Molecular Formula | C17H19NO5 |
| Molecular Weight | 317.3365 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:27:42 GMT 2023
by
admin
on
Sat Dec 16 10:27:42 GMT 2023
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| Record UNII |
YQ9CYR6ZJM
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English |
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260561-48-6
Created by
admin on Sat Dec 16 10:27:42 GMT 2023 , Edited by admin on Sat Dec 16 10:27:42 GMT 2023
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444659-42-1
Created by
admin on Sat Dec 16 10:27:42 GMT 2023 , Edited by admin on Sat Dec 16 10:27:42 GMT 2023
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SUPERSEDED | ChemIDplus: Substance Name: KF 66490, RN: 260561-48-6; Other Registry Numbers: 444659-42-1 | ||
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YQ9CYR6ZJM
Created by
admin on Sat Dec 16 10:27:42 GMT 2023 , Edited by admin on Sat Dec 16 10:27:42 GMT 2023
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
KF66490 is a newly developed PDE4 inhibitor that inhibits PDE4B (IC50 = 220 nM) and the production of tumor necrosis factor (TNF)-α by mouse peritoneal exudated cells stimulated with lipopolysaccharide (IC50 = 855 nM). The present results suggest that KF66490 has excellent potential as an oral medicine for the treatment of atopic dermatitis.
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ACTIVE MOIETY |
Other Registry Numbers: 444659-42-1, 1051982-38-7
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ACTIVE MOIETY |
A Practical Synthesis of the PDE4 Inhibitor, KW-4490
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