Luvagrobart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 20:11:21 GMT 2023` Edited by `admin` on `Sat Dec 16 20:11:21 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	YEH533V6Y3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Luvagrobart

Official Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens NGF (nerve growth factor, NGFB, nerve growth factor beta polypeptide)], humanized monoclonal antibody

Common Name

English

luvagrobart [INN]

Common Name

English

AK-115

Code

English

Gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV4-38-2*02 (80.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.15] (26-33.51-57.96-110)) (1-121) -Homo sapiens IGHG1*01 (100%), G1m17,1, CH1 K120, CH3 D12, L14, G1v14 CH2 A1.3, A1.2 (CH1 K120 (218) (1

Common Name

English

AK115

Code

English

Immunoglobulin G1 [238-alanine,239-alanine],anti-(human β-nerve growth factor) (human monoclonal AK115 γ1-chain), disulfide with human monoclonal AK115 κ-chain, dimer

Common Name

English

Code System Code Type Description

INN

12725

Created by admin on Sat Dec 16 20:11:22 GMT 2023 , Edited by admin on Sat Dec 16 20:11:22 GMT 2023

PRIMARY

CAS

2768355-18-4

Created by admin on Sat Dec 16 20:11:22 GMT 2023 , Edited by admin on Sat Dec 16 20:11:22 GMT 2023

PRIMARY

FDA UNII

YEH533V6Y3

Created by admin on Sat Dec 16 20:11:22 GMT 2023 , Edited by admin on Sat Dec 16 20:11:22 GMT 2023

PRIMARY

From	To
1_22	1_95
2_22	2_95
2_148	2_204
2_224	4_214
2_265	2_325
1_148	1_204
2_371	2_429
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_224	3_214
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					V7FWP1D62O

NERVE GROWTH FACTOR

TARGET->LIGAND

Amount:

Related Record Type Details


					YEH533V6Y3

Luvagrobart

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL