Ro-48-8071

CN(CCCCCCOC1=CC(F)=C(C=C1)C(=O)C2=CC=C(Br)C=C2)CC=C

InChIKey=CMYCCJYVZIMDFU-UHFFFAOYSA-N

InChI=1S/C23H27BrFNO2/c1-3-14-26(2)15-6-4-5-7-16-28-20-12-13-21(22(25)17-20)23(27)18-8-10-19(24)11-9-18/h3,8-13,17H,1,4-7,14-16H2,2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Lanosterol synthase 4 Target ID: P48449 Gene ID: 4047.0 Gene Symbol: LSS Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/22533316	Inhibitor 8504		5.7 nM [IC50]

PubMed

Title	Date	PubMed
Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.	2012-06-14	22533316

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:57:56 GMT 2025` Edited by `admin` on `Tue Apr 01 16:57:56 GMT 2025`
Record UNII	YDR69X9Q9M
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Ro 48-8071

Preferred Name

English

Ro-48-8071

Code

English

Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-

Systematic Name

English

Code System Code Type Description

PUBCHEM

1949