CAROTUXIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 22:04:43 GMT 2025` Edited by `admin` on `Mon Mar 31 22:04:43 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	MOUSE CHIMERIC
Sequence Type	COMPLETE
Record UNII	YB2EWE6139
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CAROTUXIMAB

Official Name

English

carotuximab [INN]

Preferred Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HUMAN ENDOGLIN (CD105 ANTIGEN)) HUMAN MOUSE CHIMERIC MONOCLONAL ANTIBODY .GAMMA.1 HEAVY CHAIN (1-448) (MOUSE VH (MUS MUSCULUS IGHV6-6*01 (98%) (IGHD)-IGHJ2*01 (87%)) (8.10.9) (1-118) -HOMO SAPIENS IGHG1*01 (119-448)) (221-2

Systematic Name

English

Carotuximab [WHO-DD]

Common Name

English

GAMMA1 HEAVY CHAIN (1-448) (MUS MUSCULUS VH (IGHV6-6*01-(IGHD) -IGHJ2*01) (8.10.9) (1-118) -HOMO SAPIENSIGHG1*01, GM17,1 (CH1 (119-216), HINGE (217-231), CH2(232-341), CH3 (342-446), CHS (447-448)) (119-448)), (221-213')-DISULFIDE WITH KAPPA LIGHT CHAIN

Common Name

English

C-SN6J

Code

English

TRC105

Code

English

TRC-105

Code

English

CAROTUXIMAB [USAN]

Common Name

English

DE-122

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN ENDOGLIN) (HUMAN-MUS MUSCULUS MONOCLONAL TRC105 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL TRC105 .KAPPA.-CHAIN, DIMER

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1742

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

NCI_THESAURUS

C20401

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

NCI_THESAURUS

C129822

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

FDA ORPHAN DRUG

504715

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

Code System Code Type Description

INN

10244

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

WIKIPEDIA

Carotuximab

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

USAN

EF-64

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

DRUG BANK

DB06322

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

ChEMBL

CHEMBL2109321

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

NCI_THESAURUS

C74010

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

SMS_ID

100000175052

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

FDA UNII

YB2EWE6139

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

CAS

1268714-50-6

Created by admin on Mon Mar 31 22:04:43 GMT 2025 , Edited by admin on Mon Mar 31 22:04:43 GMT 2025

PRIMARY

From	To
1_22	1_98
1_145	1_201
1_262	1_322
1_368	1_426
2_22	2_98
2_145	2_201
2_262	2_322
2_368	2_426
1_221	3_213
2_221	4_213
1_227	2_227
1_230	2_230
3_23	3_87
3_133	3_193
4_23	4_87
4_133	4_193

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					1Y8Q34P575

ENDOGLIN

TARGET -> INHIBITOR

Related Record Type Details


					YB2EWE6139

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:SEQUENCE(CALCULATED)	CHEMICAL