CARSATRIN SUCCINATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C25H26F2N6OS.C4H6O4
Molecular Weight	614.663
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCC(O)=O.OC(CSC1=C2N=CN=C2N=CN1)CN3CCN(CC3)C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5

InChI

InChIKey=HITUQCDKZKCYIZ-UHFFFAOYSA-N

InChI=1S/C25H26F2N6OS.C4H6O4/c26-19-5-1-17(2-6-19)23(18-3-7-20(27)8-4-18)33-11-9-32(10-12-33)13-21(34)14-35-25-22-24(29-15-28-22)30-16-31-25;5-3(6)1-2-4(7)8/h1-8,15-16,21,23,34H,9-14H2,(H,28,29,30,31);1-2H2,(H,5,6)(H,7,8)

HIDE SMILES / InChI

Molecular Formula	C4H6O4
Molecular Weight	118.088
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C25H26F2N6OS
Molecular Weight	496.575
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10525108 | https://www.ncbi.nlm.nih.gov/pubmed/7505352

Carsatrin (also known as RWJ 24517) is purinylpiperazine derivative patented by Ortho Pharmaceutical Corp. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+,K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin

Originator

Approval Year

PubMed

Title	Date	PubMed
Modification of cardiac Na(+) current by RWJ 24517 and its enantiomers in guinea pig ventricular myocytes.	1999-11	10525108

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:30:59 GMT 2025` Edited by `admin` on `Mon Mar 31 18:30:59 GMT 2025`
Record UNII	YAZ544QOFD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARSATRIN SUCCINATE

Official Name

English

RWJ 24517

Preferred Name

English

CARSATRIN SUCCINATE [USAN]

Common Name

English

RWJ-24517

Code

English

1-PIPERAZINEETHANOL, 4-(BIS(4-FLUOROPHENYL)METHYL)-.ALPHA.-((9H-PURIN-6-YLTHIO)METHYL)-, (±)-, BUTANEDIOATE (1:1) (SALT)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78322