| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H20O5S |
| Molecular Weight | 336.403 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)OC(=O)C(OCC2CC2)=C1C3=CC=C(C=C3)S(C)(=O)=O
InChI
InChIKey=FULAPETWGIGNMT-UHFFFAOYSA-N
InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
| Molecular Formula | C17H20O5S |
| Molecular Weight | 336.403 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
PubMed
Patents
Sample Use Guides
The recommended dosage of PREVICOX (firocoxib) for oral administration in dogs is 2.27 mg/lb (5.0 mg/kg) body weight once daily as needed for osteoarthritis and for 3 days as needed for postoperative pain and inflammation associated with soft-tissue and orthopedic surgery. The recommended dosage of EQUIOXX (firocoxib) for oral administration in horses is 0.045 mq/lb (0.1 mg/kg) of body weight once daily for up to 14 days. The recommended dosage of EQUIOXX Injection for intravenous administration in horses is 0.04 mg/lb (0.09 mg/kg) of body weight once daily for up to 5 days.
Route of Administration:
Other
Equine peripheral blood mononuclear cells were isolated by density gradient centrifugation and incubated at 37C with medium alone, firocoxib (100 ng/mL), LPS (1 ng/mL or 1 ug/mL), or combinations of firocoxib and both LPS concentrations. After 4 hours, supernatants were collected and tested for prostaglandin E2 (PGE2) concentration with an enzyme inhibition assay, and gene expression in cell lysates was measured with PCR assays.
