RO-31-7549

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H22N4O2
Molecular Weight	398.4571
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C=C(C2=C1C=CC=C2)C3=C(C(=O)NC3=O)C4=CN(CCCN)C5=C4C=CC=C5

InChI

InChIKey=UQHKJRCFSLMWIA-UHFFFAOYSA-N

InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)

HIDE SMILES / InChI

Molecular Formula	C24H22N4O2
Molecular Weight	398.4571
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein kinase C (PKC) 44 Target ID: CHEMBL2094266 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9257375\|https://adisinsight.springer.com/drugs/800001272	Inhibitor 8504		75.0 nM [IC50]
Protein kinase C (PKC) 44 Target ID: CHEMBL2093867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8440894	Inhibitor 8504

PubMed

Title	Date	PubMed
Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2 pathway.	2003-12	14557379

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:07:43 GMT 2025` Edited by `admin` on `Mon Mar 31 19:07:43 GMT 2025`
Record UNII	Y6197FQK8I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BISINDOLYLMALEIMIDE VIII

Preferred Name

English

RO-31-7549

Common Name

English

RO 31-7549

Common Name

English

1H-PYRROLE-2,5-DIONE, 3-(1-(3-AMINOPROPYL)-1H-INDOL-3-YL)-4-(1-METHYL-1H-INDOL-3-YL)-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB01946