FLUMIZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H15F3N2O2
Molecular Weight	348.3191
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C2=C(N=C(N2)C(F)(F)F)C3=CC=C(OC)C=C3

InChI

InChIKey=OPYFPDBMMYUPME-UHFFFAOYSA-N

InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)

HIDE SMILES / InChI

Molecular Formula	C18H15F3N2O2
Molecular Weight	348.3191
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/810570 | https://www.ncbi.nlm.nih.gov/pubmed/618737

FLUMIZOLE, a substituted diarylimidazole, is a weak acidic, nonsteroidal, anti-inflammatory agent. It is a potent cyclooxygenase inhibitor. FLUMIZOLE is severalfold more potent than indomethacin and 470 times more active than phenylbutazone in a system examining prostaglandin production.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Flumizole, a new nonsteroidal anti-inflammatory agent.	1975 Sep	810570
Disposition and activity in experimental allergic encephalomyelitis of flumizole, a nonacidic, nonsteroidal, anti-inflammatory agent.	1978 Jan 1	618737
TXA2-antagonistic properties of agents affecting prostaglandin synthesis or the cyclic nucleotide system in human platelets.	1983 Aug	6624480

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:10:30 GMT 2023` Edited by `admin` on `Fri Dec 15 17:10:30 GMT 2023`
Record UNII	Y4YQF944N9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUMIZOLE

Official Name

English

CP-22665

Code

English

flumizole [INN]

Common Name

English

4,5-BIS(P-METHOXYPHENYL)-2-(TRIFLUOROMETHYL)IMIDAZOLE

Common Name

English

FLUMIZOLE [USAN]

Common Name

English

CP-22,665

Code

English

1H-IMIDAZOLE, 4,5-BIS(4-METHOXYPHENYL)-2-(TRIFLUOROMETHYL)-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID10190204