U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C18H15F3N2O2
Molecular Weight 348.3191
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUMIZOLE

SMILES

COC1=CC=C(C=C1)C2=C(N=C(N2)C(F)(F)F)C3=CC=C(OC)C=C3

InChI

InChIKey=OPYFPDBMMYUPME-UHFFFAOYSA-N
InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)

HIDE SMILES / InChI

Molecular Formula C18H15F3N2O2
Molecular Weight 348.3191
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

FLUMIZOLE, a substituted diarylimidazole, is a weak acidic, nonsteroidal, anti-inflammatory agent. It is a potent cyclooxygenase inhibitor. FLUMIZOLE is severalfold more potent than indomethacin and 470 times more active than phenylbutazone in a system examining prostaglandin production.

CNS Activity

Originator

Approval Year

PubMed

Substance Class Chemical
Record UNII
Y4YQF944N9
Record Status Validated (UNII)
Record Version