LIFIBRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H21Cl2NO4
Molecular Weight	410.291
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC(CC1)OC(=O)C(OC2=CC=C(Cl)C=C2)OC3=CC=C(Cl)C=C3

InChI

InChIKey=QDGIAPPCJRFVEK-UHFFFAOYSA-N

InChI=1S/C20H21Cl2NO4/c1-23-12-10-18(11-13-23)25-19(24)20(26-16-6-2-14(21)3-7-16)27-17-8-4-15(22)5-9-17/h2-9,18,20H,10-13H2,1H3

HIDE SMILES / InChI

Molecular Formula	C20H21Cl2NO4
Molecular Weight	410.291
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1135523 | https://www.ncbi.nlm.nih.gov/pubmed/5811622 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 732, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Lifibrate is the antihyperlipidemic agent. It is a potent hepatic peroxisome proliferator. Administration of lifibrate at a dietary concentration of 0.15% for 3 weeks, increased the activity of catalase in both liver and kidney of male wild type (Cs-a strain) mice. The hypolipidemic activity of lifibrate is eight to nine times greater than that of chlorphenoxy isobutyric acid ethyl ester in the male Wistar rat.

Approval Year

PubMed

Title	Date	PubMed
Phosphoglyceride biosynthesis by brain microsomes: centrophenoxine, SaH-42-348, and DH-990 inhibit phospholipid N-methylation.	1984-11-15	6437335
Hypolipidemic drugs are inhibitors of phosphatidylcholine synthesis.	1982-11	6294663
Hypolipidemic activity of in vitro inhibitors of hepatic and intestinal sn-glycerol-3-phosphate acyltransferase and phosphatidate phosphohydrolase.	1977-06	197974
Morphometric analysis of the ultrastructural changes in rat liver induced by the peroxisome proliferator SaH 42-348.	1976-12	993270
1-methyl-4piperidyl-bis (P-chlorophenoxy) acetate: a new hypolipidemic peroxisome proliferator.	1975-03	1135523
Effect of SaH 42-348, an analog of clofibrate, on lipid metabolism in rats.	1973-06	4740771
Laboratory studies of 1-methyl-4-piperidyl bis(p-chlorophenoxy) acetate (SaH 42-348)--a new hypolipidemic agent.	1969-08	5811622

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:49:43 GMT 2025` Edited by `admin` on `Mon Mar 31 17:49:43 GMT 2025`
Record UNII	Y4X961F8Z1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

42-348

Preferred Name

English

LIFIBRATE

Official Name

English

lifibrate [INN]

Common Name

English

LIFIBRATE [USAN]

Common Name

English

ACETIC ACID, BIS(4-CHLOROPHENOXY)-, 1-METHYL-4-PIPERIDINYL ESTER

Common Name

English

1-METHYL-4-PIPERIDYL GLYOXYLATE 2-(BIS(P-CHLOROPHENYL) ACETAL)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98150