U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:24:02 GMT 2023
Edited
by admin
on Sat Dec 16 18:24:02 GMT 2023
Source Materials Class ORGANISM
Source Materials Type VIRUS
Source Materials State LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family Parvovirus
Organism Genus Dependoparvovirus
Infraspecific Type SUBSTRAIN
Infraspecific Name AAVrh74-ApoE HCR-hAA-alpha-glucosidase
Part whole
Record UNII
Y47XZ2EW2J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VANGLUSAGENE ENSIPARVOVEC
USAN   INN  
Official Name English
DNA (recombinant adeno-associated virus vector AAV-Spark100-GAA human liver-specific expression cassette including human lysosomal α-glucosidase codon-optimized gene GAA plus adeno-associated virus 2 inverted terminal repeat flanks)
Common Name English
SPK3006
Code English
A recombinant liver-directed adeno-associated virus vector expressing human acid alpha-glucosidase (GAA). A recombinant liver-directed adeno-associated virus serotype rh74 (AAVrh74) vector that contains a bioengineered capsid derived from AAVrh74 by four
Common Name English
vanglusagene ensiparvovec [INN]
Common Name English
VANGLUSAGENE ENSIPARVOVEC [USAN]
Common Name English
SPK-3006
Code English
Code System Code Type Description
FDA UNII
Y47XZ2EW2J
Created by admin on Sat Dec 16 18:24:02 GMT 2023 , Edited by admin on Sat Dec 16 18:24:02 GMT 2023
PRIMARY
CAS
2382896-00-4
Created by admin on Sat Dec 16 18:24:02 GMT 2023 , Edited by admin on Sat Dec 16 18:24:02 GMT 2023
PRIMARY
NCI_THESAURUS
C180664
Created by admin on Sat Dec 16 18:24:02 GMT 2023 , Edited by admin on Sat Dec 16 18:24:02 GMT 2023
PRIMARY
INN
11603
Created by admin on Sat Dec 16 18:24:02 GMT 2023 , Edited by admin on Sat Dec 16 18:24:02 GMT 2023
PRIMARY
USAN
JK-90
Created by admin on Sat Dec 16 18:24:02 GMT 2023 , Edited by admin on Sat Dec 16 18:24:02 GMT 2023
PRIMARY
Related Record Type Details
EXPRESSED PROTEIN->VECTOR
EXPRESSED PROTEIN->VECTOR

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
TRANSGENE VANGLUSAGENE ENSIPARVOVEC TRANSGENE INSERT 2S4PWR7ZEU