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Details

Stereochemistry ACHIRAL
Molecular Formula C23H27ClN2O2
Molecular Weight 398.926
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of PINOXEPIN

SMILES

OCCN1CCN(CC\C=C2\C3=C(COC4=C2C=C(Cl)C=C4)C=CC=C3)CC1

InChI

InChIKey=RAAHIUIRJUOMAU-MPUCSWFWSA-N
InChI=1S/C23H27ClN2O2/c24-19-7-8-23-22(16-19)21(20-5-2-1-4-18(20)17-28-23)6-3-9-25-10-12-26(13-11-25)14-15-27/h1-2,4-8,16,27H,3,9-15,17H2/b21-6-

HIDE SMILES / InChI

Molecular Formula C23H27ClN2O2
Molecular Weight 398.926
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Pinoxepin belongs to the dibenzoxepine series of drugs which are characterized by a 6-7-6 tricyclic nuclear structure. Clinical studies indicated that pinoxepin was a potent antipsychotic-sedative equally effective to chlorpromazine and thioridazine. Pinoxepin in studies with chronic schizophrenic patients displayed useful effects on behavior without unduly prominent side effects. In doses above 300 mg seizures are reported and more frequent changes in liver-function tests were noted than with standard drug, but below 300 mg pinoxepin was found to have side effects similar to chlorpromazine and marked sedative effects.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
Daily dosage: 50 mg - 1st week, 100mg - 2nd week, 150 mg - 3rd week, 200 mg - 4th week, 250 mg - 5th week, 250-400 mg - 6-10th weeks.
Route of Administration: Oral
Substance Class Chemical
Record UNII
Y3YKO9X8N8
Record Status Validated (UNII)
Record Version