Details
Stereochemistry | RACEMIC |
Molecular Formula | C13H14N2O |
Molecular Weight | 214.2631 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=C2C=CC=CC2=NC3=C1C(O)CCC3
InChI
InChIKey=HLVVITIHAZBPKB-UHFFFAOYSA-N
InChI=1S/C13H14N2O/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15)
Molecular Formula | C13H14N2O |
Molecular Weight | 214.2631 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Velnacrine (9-amino-1,2,3,4-tetrahydroacridin-1-ol) is an inhibitor of acetylcholinesterase. It was studied for the treatment of Alzheimer's disease however development was discontinued. There has been no research into the use of velnacrine as a cognitive enhancer in the treatment of Alzheimer's disease since 1994. The FDA peripheral and CNS drug advisory board voted unanimously against recommending approval. This review shows the toxic nature of velnacrine, and provides no evidence of efficacy.
Originator
Approval Year
Sample Use Guides
Velnacrine for the treatment of Alzheimer's disease (a double-blind, placebo-controlled trials): 10, 25, 50 and 75 mg t.i.d. The 225 mg/day dose appears to be safe for use in multicenter outpatient trials of velnacrine efficacy in Alzheimer's disease.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 22:17:57 UTC 2022
by
admin
on
Fri Dec 16 22:17:57 UTC 2022
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Record UNII |
Y2P6NV151K
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C47792
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Code System | Code | Type | Description | ||
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CHEMBL51934
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M983
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PRIMARY | Merck Index | ||
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104675-29-8
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3655
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C056424
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Y2P6NV151K
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6403
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SUB00033MIG
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DTXSID4046945
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3848
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124027-47-0
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C96773
Created by
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
Related Record | Type | Details | ||
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PARENT -> METABOLITE |
URINE
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Related Record | Type | Details | ||
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ACTIVE MOIETY |